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CAS 65147-06-0

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Boc-Ile-Glu-Gly-Arg-AMC

Beschreibung:
Boc-Ile-Glu-Gly-Arg-AMC ist ein synthetisches Peptidsubstrat, das häufig in der biochemischen Forschung verwendet wird, insbesondere in Studien, die proteolytische Enzyme betreffen. Der Name weist darauf hin, dass es sich um ein Derivat der Aminosäuren Isoleucin (Ile), Glutaminsäure (Glu), Glycin (Gly) und Arginin (Arg) handelt, mit einer Boc (tert-Butyloxycarbonyl)-Schutzgruppe am Isoleucin-Rest. Die AMC (7-Amino-4-methylcoumarin)-Gruppe dient als fluoreszierender Reporter, der die Überwachung der enzymatischen Aktivität durch Fluoreszenz-Assays ermöglicht. Diese Verbindung wird typischerweise in Assays verwendet, um Proteasen zu untersuchen, da die Spaltung der Peptidbindung durch das Enzym die AMC-Gruppe freisetzt, was zu einer Zunahme der Fluoreszenz führt, die quantitativ gemessen werden kann. Die Stabilität der Boc-Gruppe unter bestimmten Bedingungen macht sie für verschiedene experimentelle Setups geeignet. Insgesamt ist Boc-Ile-Glu-Gly-Arg-AMC ein wertvolles Werkzeug im Bereich der Enzymologie und Peptidchemie, das das Verständnis der Enzymkinetik und der Substratspezifität unterstützt.
Formel:C34H50N8O10
InChl:InChI=1/C34H50N8O10/c1-7-18(2)28(42-33(50)52-34(4,5)6)31(49)40-23(12-13-26(44)45)29(47)38-17-25(43)41-30(48)22(9-8-14-37-32(35)36)39-20-10-11-21-19(3)15-27(46)51-24(21)16-20/h10-11,15-16,18,22-23,28,39H,7-9,12-14,17H2,1-6H3,(H,38,47)(H,40,49)(H,42,50)(H,44,45)(H4,35,36,37)(H,41,43,48)/t18-,22-,23-,28-/m0/s1
SMILES:CC[C@H](C)[C@@H](C(=N[C@@H](CCC(=O)O)C(=NCC(=NC(=O)[C@H](CCCNC(=N)N)Nc1ccc2c(C)cc(=O)oc2c1)O)O)O)N=C(O)OC(C)(C)C
Synonyme:
  • tertiary-Butyloxycarbonyl-isoleucyl-glutamyl-glycyl-arginyl-7-amino-4-methylcoumarin
  • Biggam
  • Boc-ile-glu-gly-arg-mca
  • L-Argininamide, N-((1,1-dimethylethoxy)carbonyl)-L-isoleucyl-L-alpha-glutamylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
  • N-(tert-butoxycarbonyl)-L-isoleucyl-L-alpha-glutamyl-N-{(2S)-5-[(diaminomethylidene)amino]-2-[(4-methyl-2-oxo-2H-chromen-7-yl)amino]pentanoyl}glycinamide
  • Boc-Ile-Glu-Gly-Arg-Amc Acetate Salt
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4 Produkte.
  • Boc-Ile-Glu-Gly-Arg-AMC
    Bachem
    + Info

    Boc-Ile-Glu-Gly-Arg-AMC

    CAS:
    Boc-IEGR-AMC, a specific, highly fluorogenic substrate for clotting enzyme factor Xa (coagulation factor Xa). Boc-IEGR-AMC is also hydrolyzed by acrosin from the ascidian Halocynthia roretzi. The use of this substrate in the indirect determination of coagulation factor IX has been described.
    Formel:C34H50N8O10
    Reinheit:97.8%
    Farbe und Form:White Powder
    Molekulargewicht:730.82

    Ref: 01-4004961

    25mg
    337,00€
    100mg
    982,00€
  • Boc-Ile-Glu-Gly-Arg-AMC
    Targetmol
    + Info

    Boc-Ile-Glu-Gly-Arg-AMC

    CAS:
    <p>Boc-IEGR-AMC: fluorogenic substrate for factor Xa and Halocynthia roretzi acrosin.</p>
    Formel:C34H50N8O10
    Reinheit:98%
    Farbe und Form:White Powder
    Molekulargewicht:730.81

    Ref: TM-TP1129

  • Boc-Ile-Glu-Gly-Arg-AMC
    Biosynth
    + Info

    Boc-Ile-Glu-Gly-Arg-AMC

    CAS:
    <p>Boc-Ile-Glu-Gly-Arg-AMC is a cell permeable inhibitor of protein interactions that binds to the peptide sequences of the extracellular domain of the epidermal growth factor receptor (EGFR). Boc-Ile-Glu-Gly-Arg-AMC can be used as a research tool to study protein interactions, as well as an inhibitor for EGFR. It is soluble in DMSO and water. This product has been shown to inhibit the activity of ion channels such as voltage dependent calcium channels, potassium channels, and sodium channels. Boc-Ile-Glu-Gly-Arg-AMC also inhibits antibody binding to its antigen.</p>
    Formel:C34H50N8O10
    Reinheit:Min. 95%
    Molekulargewicht:730.81 g/mol

    Ref: 3D-MIE-3094-V

    5mg
    278,00€
  • Boc-Ile-Glu-Gly-Arg-AMC acetate salt
    Biosynth
    + Info

    Boc-Ile-Glu-Gly-Arg-AMC acetate salt

    CAS:
    <p>Boc-Ile-Glu-Gly-Arg-AMC acetate salt is a homologous peptide derived from soybean trypsin inhibitor. It has a molecular weight of 7,000 daltons and inhibits the activity of serine proteases, including kallikrein, plasmin, and thrombin. This peptide has been shown to be an inhibitor of heparin coagulation factor Xa and tissue factor in vitro. Boc-Ile-Glu-Gly-Arg-AMC acetate salt also has anticoagulant properties in vivo which are due to its ability to inhibit the synthesis of prothrombin.</p>
    Formel:C34H50N8O10·C2H4O2
    Reinheit:Min. 95%
    Farbe und Form:Solid
    Molekulargewicht:790.86 g/mol

    Ref: 3D-FB110485

    1g
    1.998,00€