CAS 71-63-6

Digitoxin

Beschreibung:

Digitoxin ist ein Herzglykosid, das aus der Pflanze Digitalis purpurea, allgemein bekannt als Fingerhut, gewonnen wird. Es wird hauptsächlich zur Behandlung von Herzkrankheiten eingesetzt, insbesondere bei Herzinsuffizienz und Vorhofflimmern, aufgrund seiner Fähigkeit, die Kraft der Herzkontraktionen zu erhöhen und den Herzrhythmus zu regulieren. Die chemische Struktur von Digitoxin umfasst einen Steroidkern mit einem Laktonring und mehreren Zuckermolekülen, die zu seinen pharmakologischen Eigenschaften beitragen. Es ist lipophil, was ihm ermöglicht, Zellmembranen leicht zu durchdringen, und hat eine relativ lange Halbwertszeit, was eine sorgfältige Überwachung der Dosierung zur Vermeidung von Toxizität erfordert. Zu den häufigen Nebenwirkungen gehören gastrointestinale Störungen, visuelle Veränderungen und potenzielle Arrhythmien, insbesondere bei Überdosierung. Der Wirkmechanismus von Digitoxin beinhaltet die Hemmung der Na+/K+ ATPase-Pumpe, was zu erhöhten intrazellulären Calciumspiegeln führt, die die Herzkontraktionskraft verbessern. Aufgrund seines engen therapeutischen Index erfordert Digitoxin eine sorgfältige Dosierung und Überwachung in klinischen Umgebungen.

Formel: C₄₁H₆₄O₁₃

InChl: InChI=1/C41H64O13/c1-20-36(46)29(42)16-34(49-20)53-38-22(3)51-35(18-31(38)44)54-37-21(2)50-33(17-30(37)43)52-25-8-11-39(4)24(15-25)6-7-28-27(39)9-12-40(5)26(10-13-41(28,40)47)23-14-32(45)48-19-23/h14,20-22,24-31,33-38,42-44,46-47H,6-13,15-19H2,1-5H3/t20-,21-,22-,24-,25+,26-,27?,28?,29+,30+,31+,33+,34+,35+,36-,37-,38-,39+,40-,41+/m1/s1

InChI Key: InChIKey=WDJUZGPOPHTGOT-XUDUSOBPSA-N

SMILES: O[C@@]12[C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@@H](O[C@H]5C[C@H](O)[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O)[C@@H](C)O7)[C@@H](C)O6)[C@@H](C)O5)CC4)[H])(CC[C@]1(C)[C@H](CC2)C=8COC(=O)C8)[H])[H]

Synonyme:

• (3beta,5beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-14-hydroxycard-20(22)-enolide
• (3beta,5beta,8xi,9xi)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-14-hydroxycard-20(22)-enolide
• (3β,5β)-3-[(O-2,6-Dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
• 3-{[2,6-Dideoxyhexopyranosyl-(1->4)-2,6-Dideoxyhexopyranosyl-(1->4)-2,6-Dideoxyhexopyranosyl]Oxy}-14-Hydroxycard-20(22)-Enolide
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3β,5β)-
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3β,5β)-
• Cardidigin
• Cardigin
• Carditoxin
• Coramedan
• Cristapurat
• Crystalline digitalin
• Crystodigin
• Digicor
• Digilong
• Digimed
• Digimerck
• Digipural
• Digisidin
• Digitaline Nativelle
• Digitophyllin
• Digitoxigenin tridigitoxoside
• Digitoxina
• Digitoxine
• Digitoxoside
• Digitrin
• Ditaven
• Glucodigin
• Lanatoxin
• Myodigin
• Nsc 7529
• Purodigin
• Purpurid
• Tradigal
• Unidigin
• Digitoxin
• (3β,5β)-3-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
• 4)-O-2,6-dideoxy-b-D-ribo-hexopyranosyl-(1&reg
• Digitoksin
• Acedoxin
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1.-&gt
• mono-digitoxid
• monodigitoxoside
• Card-20(22)-enolide,3-[(O-2,6-dideoxy-b-D-ribo-hexopyranosyl-(1&reg
• .4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3beta,5beta)-
• 4)-2,6-dideoxy-b-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3b,5b)-
• digitoxigenin-tridigitoxosid
• Tri-digitoxoside
• digitalinecristallisee
• (3beta,5beta)-3-((O-2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14-hydroxy-card-20(22)-enolide
• DIGITALIN
• Purodigin, crystalline
• 4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3beta,5beta)-
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1--&gt
• digitoksim
• Digitoxin ,>=95%
• Digitaline cristallisee
• Digtoxoside
• hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-
• digitoxinum
• digitoxigenintridigitoxoside
• 6-dideoxy-beta-d-ribo-o-6-dideoxy-beta-d-ribo-hexopyranosyl-(1.fwdarw.4)-2
• Tardigal
• Digitoxin (8CI)
• hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(14)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(14)-2,6-dideoxy-beta-D-ribo-hexopyranosyl
• digitalin,crystalline
• Digitoxin,5β,20(22)-Cardenolide-3β,14-diol-3-(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-[1→4]-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-[1→4]-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy
• ta-d-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-d-ribo-hexopyranosyl)oxy)-14-hy
• Digitogenin
• Digitoxin solution
• mono-glycocard
• Cristodigin
• (3beta,5beta)-y)-14-hydroxy
• 4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1--&gt
• 5beta-Card-20(22)-enolide, 3beta,14-dihydroxy-, 3-(tris-(digitoxoside))
• (3beta,5beta)-3-((o-2,6-dideoxy-beta-d-ribohexopyranosyl-(1-4)-o-2,6-dideoxy-be
• 3-((2,6-Dideoxy-4-O-[2,6-dideoxy-4-O-(2,6-dideoxyhexopyranosyl)hexopyranosyl]hexopyranosyl)oxy)-14-hydroxycard-20(22)-enolide
• Card-20(22)-enolide, 3-(O-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl-(1?4)-O-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl-(1?4)-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl)oxy-14-hydroxy-, (3.beta.,5.beta.)-
• carditalin
• digitalinenativelle
• hexopyranosyl)oxy]-14-hydroxy-, (3β,5β)-
• DIGITOXIN CRYSTALLINE
• Digitalinum verum
• 5β,20(22)-cardenolide-3β,14-diol-3-(o-2,6-dideoxy-β-d-ribo-hexopyranosyl-[1→4]-o-2,6-dideoxy-β-d-ribo-hexopyranosyl-[1→4]-2,6-dideoxy-β-d-ribo-hexopyranosyl)oxy
• Digitoxin,99%
• Digitoxoside (7CI)
• (3beta,5beta)-hexopyranosyl)oxy]-14-hydroxy
• Digitoxin (200 mg)
• Card-20(22)-enolide, 3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14-hydroxy-, (3beta,5beta)-
• .4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1.-&gt
• De-Tone
• (3,5)-3-[(O-2,6-Dideoxy--D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy--D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy--D-ribo-hexopyranosyl)oxyl]-14-hydroxycard-20(22)-enolide
• Natigal
• DIGITOXIN,USP
• asthenthilo
• 3-[(o-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.fwdarw.4)-card-20(22)-enolid
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-
• DIGITOXIN(P)
• 20(22),5BETA-CARDENOLID-3BETA,14BETA-DIOL 3BETA-2,6-DIDEOXY-(4->O)-[2,6-DIDEOXY-4(4->O)-(2,6-DIDEOXY-BETA-D-RIBOHEXOPYRANOSYL)-BETA-D-RIBOHEXOPYRANOSID]
• 5BETA,20[22]-CARDENOLIDE-3BETA,14-DIOL-3[O-2,6-DIDEOXY-BETA-D-RIBO-HEXOPYRANOSYL-(1->4)-O-2,6-DIDEOXY-BETA-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-BETA-D-RIBO-HEXOPYRANOSYL]OXY
• (3b,5b)-3-[(O-2,6-Dideoxy-b-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-b-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-b-D-ribo-hexopyranosyl)oxyl]-14-hydroxycard-20(22)-enolide
• digitalinumverum

Digitoxin

CAS: 71-63-6

Formel: C₄₁H₆₄O₁₃

Reinheit: >97.0%(HPLC)

Farbe und Form: White to Almost white powder to crystal

Molekulargewicht: 764.95

Ref: 3B-D0542

Digitoxin

CAS: 71-63-6

Digitoxin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formel: C₄₁H₆₄O₁₃

Reinheit: (HPLC) ≥98%

Farbe und Form: Powder

Molekulargewicht: 764.96

Ref: 11-0814S

DIGITOXIN RS

CAS: 71-63-6

DIGITOXIN RS

Formel: C₄₁H₆₄O₁₃

Molekulargewicht: 764.9391

Ref: 41-ICRS0288

DIGITOXIN FOR LC ASSAY CRS

CAS: 71-63-6

DIGITOXIN FOR LC ASSAY CRS

Ref: 41-Y0002036

Digitoxin

CAS: 71-63-6

Digitoxin

Formel: C₄₁H₆₄O₁₃

Reinheit: 97.9%

Farbe und Form: Off-White

Molekulargewicht: 764.43469

Ref: 47-855

DIGITOXIN CRS

CAS: 71-63-6

DIGITOXIN CRS

Formel: C₄₁H₆₄O₁₃

Farbe und Form: Powder. White. Whitish.

Molekulargewicht: 764.9391

Ref: 41-D1800000

Digitoxin

CAS: 71-63-6

Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives

Formel: C₄₁H₆₄O₁₃

Farbe und Form: White Off-White Crystalline Powder

Molekulargewicht: 764.94 g/mol

Ref: 45-1199002

Digitoxin

CAS: 71-63-6

Digitoxin (Digitoxinum) is an effective Na+/K+-ATPase inhibitor (EC50 value: 0.78 μM).

Formel: C₄₁H₆₄O₁₃

Reinheit: 98.23% - 98.54%

Farbe und Form: Very Small Elongated Rectangular Plates From Dilute Alcohol 1998)

Molekulargewicht: 764.94

Ref: TM-T0295

Digitoxin (Digoxin EP Impurity A)

CAS: 71-63-6

Formel: C₄₁H₆₄O₁₃

Farbe und Form: White To Off-White Solid

Molekulargewicht: 764.95

Ref: 4Z-D-461

Digitoxin

CAS: 71-63-6

Formel: C₄₁H₆₄O₁₃

Molekulargewicht: 764.94

Ref: 7W-GC5627

Digitoxin

Kontrolliertes Produkt

CAS: 71-63-6

Formel: C₄₁H₆₄O₁₃

Farbe und Form: Neat

Molekulargewicht: 764.94

Ref: 04-C12633800

Digitoxin 100 µg/mL in Acetonitrile

CAS: 71-63-6

Formel: C₄₁H₆₄O₁₃

Farbe und Form: Single Solution

Molekulargewicht: 764.94

Ref: 04-A12633800AL-100

Digitoxin

CAS: 71-63-6

Formel: C₄₁H₆₄O₁₃

Reinheit: 95%~99%

Molekulargewicht: 764.95

Ref: BP-BP0489

Digitoxin

CAS: 71-63-6

Digitalis glycoside

Formel: C₄₁H₆₄O₁₃

Reinheit: ≥ 95.0 % (HPLC)

Farbe und Form: Powder

Molekulargewicht: 764.95

Ref: 5G-82516

Digitoxin-21,23,23-d3

Kontrolliertes Produkt

CAS: 71-63-6

Applications Isotope labelled Digitoxin (D445950), is used as a cardiotonic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Foerster, et al.: Arch. Int. Pharmacodyn. Ther., 159, 1 (1966), Jakovljevic, I.M., Anal. Profiles Drug Subs., 3, 149 (1974)

Formel: C₄₁H₆₁D₃O₁₃

Reinheit: 90%

Farbe und Form: Neat

Molekulargewicht: 767.96

Ref: TR-D445952

Digitoxin

CAS: 71-63-6

Digitoxin is a cardiac glycoside, which is a type of compound extracted primarily from the leaves of the Digitalis purpurea plant, also known as the common foxglove. This natural source provides digitoxin with its potent pharmacological properties.

Formel: C₄₁H₆₄O₁₃

Reinheit: Min. 95 Area-%

Farbe und Form: White Off-White Powder

Molekulargewicht: 764.96 g/mol

Ref: 3D-OD09336

Digitoxin

CAS: 71-63-6

Stability Hygroscopic
Applications Cardiotonic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Foerster, et al.: Arch. Int. Pharmacodyn. Ther., 159, 1 (1966), Jakovljevic, I.M., Anal. Profiles Drug Subs., 3, 149 (1974)

Formel: C₄₁H₆₄O₁₃

Farbe und Form: White To Off-White

Molekulargewicht: 764.94

Ref: TR-D445950

Digoxin EP Impurity A

CAS: 71-63-6

Formel: C₄₁H₆₄O₁₃

Molekulargewicht: 765

Ref: ST-EA-CP-D1200001

DigitoXin, USP

CAS: 71-63-6

Formel: C₄₁H₆₄O₁₃

Reinheit: 92%

Farbe und Form: Solid

Molekulargewicht: 764.9391

Ref: IN-DA003PIK