CAS 718612-62-5

Irinotecan-d10 HCl

CAS: 718612-62-5

Formel: C₃₃H₂₈D₁₀N₄O₆·HCl

Farbe und Form: Yellow Solid

Molekulargewicht: 596.75 36.46

Ref: 4Z-I-181

Irinotecan-d10 Hydrochloride (Major)

Kontrolliertes Produkt

CAS: 718612-62-5

Applications Deuterated Irinotecan, a DNA topoisomerase inhibitor.
References Kunimoto, T., et al.: Cancer Res., 47, 5944 (1987), Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1993)

Formel: C₃₃H₂₉D₁₀ClN₄O₆

Farbe und Form: Neat

Molekulargewicht: 633.2

Ref: TR-I767502

Irinotecan-d10 Hydrochloride

CAS: 718612-62-5

Irinotecan-d10 Hydrochloride is a deuterated compound of Irinotecan Hydrochloride. Irinotecan Hydrochloride has a CAS number of 100286-90-6. Irinotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.

Formel: C₃₃H₂₉D₁₀ClN₄O₆

Farbe und Form: Solid

Molekulargewicht: 633.20

Ref: TM-TMID-0078