CAS 76712-82-8

des-gly10,(D-his(bzl)6)-lh-rh*ethylamid

Beschreibung:

des-gly10,(D-his(bzl)6)-lh-rh*ethylamid, mit der CAS-Nummer 76712-82-8, ist ein synthetisches Peptidanalogon, das aus dem natürlich vorkommenden Hormon Luteinisierungshormon-freisetzendes Hormon (LHRH) abgeleitet ist. Diese Verbindung zeichnet sich durch ihre strukturellen Modifikationen aus, zu denen das Entfernen des Glycinrückstands an Position 10 und die Incorporation eines D-Histidinrückstands mit einer Benzylgruppe an Position 6 gehören. Diese Modifikationen verbessern ihre Stabilität und Bioaktivität im Vergleich zum nativen LHRH. Die Verbindung zeigt typischerweise eine hohe Affinität zu LHRH-Rezeptoren, was sie in der Forschung zur Fortpflanzungsbiologie und potenziellen therapeutischen Anwendungen bei hormonbedingten Störungen von Interesse macht. Ihre einzigartige Struktur ermöglicht eine verlängerte Wirkung in biologischen Systemen, was in klinischen Umgebungen von Vorteil sein kann. Als Peptid ist es in der Regel in wässrigen Lösungen löslich und kann spezifische Bedingungen für Lagerung und Handhabung erfordern, um seine Integrität zu bewahren. Insgesamt stellt des-gly10,(D-his(bzl)6)-lh-rh*ethylamid einen bedeutenden Fortschritt im Peptiddesign für gezielte hormonelle Therapien dar.

Formel: C₆₆H₈₆N₁₈O₁₂

InChl: InChI=1/C66H86N18O12.C2H4O2/c1-4-70-64(95)55-17-11-25-84(55)65(96)48(16-10-24-71-66(67)68)76-58(89)49(26-38(2)3)77-62(93)53(30-43-34-83(37-74-43)33-40-12-6-5-7-13-40)81-59(90)50(27-39-18-20-44(86)21-19-39)78-63(94)54(35-85)82-60(91)51(28-41-31-72-46-15-9-8-14-45(41)46)79-61(92)52(29-42-32-69-36-73-42)80-57(88)47-22-23-56(87)75-47;1-2(3)4/h5-9,12-15,18-21,31-32,34,36-38,47-55,72,85-86H,4,10-11,16-17,22-30,33,35H2,1-3H3,(H,69,73)(H,70,95)(H,75,87)(H,76,89)(H,77,93)(H,78,94)(H,79,92)(H,80,88)(H,81,90)(H,82,91)(H4,67,68,71);1H3,(H,3,4)/t47-,48-,49-,50-,51-,52-,53+,54-,55-;/m0./s1

Synonyme:

• Histrelin
• 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
• 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate (1:1)
• ^-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-pmlinamide
• 6-(1-(phenylmethyl)-d-histidine)-9-luteinizinghormonereleasingfactor(pig
• (n-ethyl-l-prolinamide)-10-deglycinamide-
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
• Supprelin
• Histreline Acetate
• histrelin acetate
• 1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)-
• 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-1-benzyl-D-His-L-Leu-L-Arg-L-Pro-N-ethyl-NH2
• RWJ-17070
• DES-GLY10,[D-HIS(BZL)6]-LH-RH ETHYLAMIDE
• [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE (HUMAN)
• ((imbl)-d-his(sub6),pro(sub9)-net)lhrh
• (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
• PYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET
• orf17070
• (HIS(BZL)6)-HISTRELIN
• (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LHRH
• Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
• 5-oxo-L-pmlyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N^
• [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LH-RH (HUMAN)
• (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LHRH
• PYR-HIS-TRP-SER-TYR-HIS(BZL)-LEU-ARG-PRO-NHET
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
• PGLU-HIS-TRP-SER-TYR-D-HIS[BZL]-LEU-ARG-PRO-NHET

Histrelin

CAS: 76712-82-8

Formel: C₆₆H₈₆N₁₈O₁₂

Molekulargewicht: 1323.50

Ref: 7W-GP6870

Histrelin

CAS: 76712-82-8

Formel: C₆₆H₈₆N₁₈O₁₂

Molekulargewicht: 1323.53

Ref: 4Z-PH-047001

Histrelin Acetate

CAS: 76712-82-8

Formel: C₆₆H₈₆N₁₈O₁₂

Reinheit: 95%~99%

Farbe und Form: White to Off-white Powder

Molekulargewicht: 1323.5

Ref: BP-BPPG040

Histrelin Acetic Acid Salt

CAS: 76712-82-8

Applications Histrelin is a gonadotropin releasing hormone analog used with the potential to improve height prospects.
References Brauner, R. et al.: Nat. Rev. Endocrinol., 11, 386 (2015);

Formel: C₆₆H₈₆N₁₈O₁₂•xCH₃COOH

Farbe und Form: Neat

Molekulargewicht: 1323.506005

Ref: TR-H456310

Histrelin Acetate

CAS: 76712-82-8

Histrelin acetate is a synthetic analog of the natural hormone histrelin. It has been used clinically to treat prostate cancer, androgenetic alopecia, and other conditions. Histrelin acetate binds to receptors in the hypothalamus and pituitary gland that are responsible for regulating the production of sex hormones. This drug is administered by injection into the pubic area or under the skin as an implant. Histrelin acetate's effectiveness is related to its suppression of gonadotropins, which results in decreased testosterone levels. Histrelin acetate also decreases testosterone production by inhibiting gonadotropin-releasing hormone from stimulating the anterior pituitary gland to produce luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The long-term efficacy of this drug has been demonstrated in clinical studies lasting up to two years with no significant adverse effects on bone mineral density or sexual function.

Reinheit: Min. 95%

Ref: 3D-FH138112