CAS 851199-59-2

Linaclotid

Beschreibung:

Linaclotid ist ein synthetisches Peptid, das hauptsächlich als Medikament zur Behandlung des Reizdarmsyndroms mit Verstopfung (IBS-C) und der chronischen idiopathischen Verstopfung (CIC) eingesetzt wird. Es wirkt als Agonist der Guanylatcyclase-C, was zu erhöhten Spiegeln von cyclischem Guanosinmonophosphat (cGMP) in den intestinalen Epithelzellen führt. Diese Wirkung fördert die Flüssigkeitssekretion in das Darmlumen und beschleunigt den gastrointestinalen Transit, wodurch die Symptome der Verstopfung gelindert werden. Linaclotid zeichnet sich durch seine relativ geringe orale Bioverfügbarkeit aufgrund seiner peptidischen Natur aus, was seine Absorption im Magen-Darm-Trakt einschränkt. Der Stoff wird typischerweise in Kapselform verabreicht und ist bekannt für seinen spezifischen Wirkmechanismus, der die Darmschleimhaut anvisiert, anstatt systemische Wege zu nutzen. Häufige Nebenwirkungen können Durchfall, Bauchschmerzen und Blähungen umfassen. Die Wirksamkeit und das Sicherheitsprofil von Linaclotid wurden durch klinische Studien etabliert, was es zu einer wertvollen Option im Management bestimmter gastrointestinaler Störungen macht.

Linaclotide

CAS: 851199-59-2

Formel: C₅₉H₇₉N₁₅O₂₁S₆

Reinheit: 99%

Farbe und Form: Solid

Molekulargewicht: 1526.7365

Ref: IN-DA00G3R9

Linaclotide

CAS: 851199-59-2

Linaclotide treats IBS-C & chronic constipation; it's a selective guanylate cyclase C agonist.

Formel: C₅₉H₇₉N₁₅O₂₁S₆

Reinheit: 97.93% - 98.71%

Farbe und Form: Solid

Molekulargewicht: 1526.74

Ref: TM-T11852

Linaclotide

CAS: 851199-59-2

Formel: C₅₉H₇₉N₁₅O₂₁S₆

Molekulargewicht: 1526.73

Ref: 4Z-PL-121001

Linaclotide

CAS: 851199-59-2

Linaclotide

Reinheit: ≥95%

Molekulargewicht: 1526.74g/mol

Ref: 54-BUP05450

Linaelotide Acetate

CAS: 851199-59-2

Formel: C₅₉H₇₉N₁₅O₂₁S₆

Reinheit: 95%~99%

Farbe und Form: White to Off-white Powder

Molekulargewicht: 1526.74

Ref: BP-BPPG045

Linaclotide-d4

CAS: 851199-59-2

Formel: C₅₉H₇₅N₁₅O₂₁S₆D₄

Molekulargewicht: 1530.78

Ref: 4Z-PL-121002

Linaclotide

CAS: 851199-59-2

Linaclotide is a drug that is used in the treatment of chronic idiopathic constipation. It is formulated with the inactive ingredients microcrystalline cellulose, croscarmellose sodium, calcium stearate, and magnesium stearate. The active ingredient is linaclotide hydrochloride. Linaclotide works by increasing intestinal motility and reducing transit time through the gastrointestinal tract. It has been shown to be effective in treating constipation in adults with chronic idiopathic constipation when taken for up to 12 weeks. Linaclotide also may be used in combination with other treatments for bowel diseases such as ulcerative colitis or Crohn's disease.
Linaclotide is metabolized primarily by cytochrome P450 3A4 (CYP3A4) and subsequently eliminated from the body primarily by renal excretion of unchanged drug or metabolites. The drug has a half-life of about 4 hours following oral administration and

Formel: C₅₉H₇₉N₁₅O₂₁S₆

Reinheit: Min. 98 Area-%

Farbe und Form: White Powder

Molekulargewicht: 1,526.74 g/mol

Ref: 3D-FL138962

Linaclotide

CAS: 851199-59-2

Linaclotide is a peptide drug that has been shown to be effective in treating chronic constipation. It belongs to the class of pharmacological agents and is used as a treatment for bowel disease, specifically chronic idiopathic constipation. Linaclotide increases the frequency of bowel movements by acting on the ileum and colon. This drug has been shown to be safe for use in pregnant women and children, with no adverse effects observed at doses up to 100 mcg/kg/day. The most common side effect is diarrhea, which can be managed with dietary changes or other medications. Linaclotide has not been found to interact with other drugs, but patients should always consult their doctor before taking any new medication while on linaclotide.

Formel: C₅₉H₇₉N₁₅O₂₁S₆

Reinheit: Min. 95%

Molekulargewicht: 1,526.76 g/mol

Ref: 3D-LIN-3796-PI

Linaclotide

Kontrolliertes Produkt

CAS: 851199-59-2

Applications Linaclotide is a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
References Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012);

Formel: C₅₉H₇₉N₁₅O₂₁S₆

Farbe und Form: Neat

Molekulargewicht: 1526.74

Ref: TR-L465880

Linaclotide-d4

Kontrolliertes Produkt

CAS: 851199-59-2

Applications Linaclotide-d4 is the labeled analogue of a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
References Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012);

Formel: C₅₉H₇₅D₄N₁₅O₂₁S₆

Farbe und Form: Neat

Molekulargewicht: 1530.76

Ref: TR-L465882