CAS 877636-42-5

ML221

CAS: 877636-42-5

Formel: C₁₇H₁₁N₃O₆S

Reinheit: 97%

Farbe und Form: Solid

Molekulargewicht: 385.3507

Ref: IN-DA01ENZJ

4-Oxo-6-((Pyrimidin-2-Ylthio)Methyl)-4H-Pyran-3-Yl 4-Nitrobenzoate

CAS: 877636-42-5

4-Oxo-6-((Pyrimidin-2-Ylthio)Methyl)-4H-Pyran-3-Yl 4-Nitrobenzoate

Reinheit: 97%

Molekulargewicht: 385.35g/mol

Ref: 54-OR1025978

ML221

CAS: 877636-42-5

ML221

Reinheit: ≥95%

Molekulargewicht: 385.35g/mol

Ref: 54-BUP05998

ML221

CAS: 877636-42-5

ML221 is a potent apelin /APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in

Formel: C₁₇H₁₁N₃O₆S

Reinheit: 97.74%

Farbe und Form: Solid

Molekulargewicht: 385.35

Ref: TM-T4390

4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate

CAS: 877636-42-5

Reinheit: 97%

Molekulargewicht: 385.3500061

Ref: 10-F867086

ML 221

CAS: 877636-42-5

ML 221 is a monoclonal antibody that specifically binds to follicular growth factor (FGF). It blocks the interaction between FGF and its receptor, thereby inhibiting follicular growth. The effects of ML 221 in vivo have been demonstrated in wild-type mice. In these mice, ML 221 inhibited the proliferation of granulosa cells, which are cells found in the ovaries responsible for producing estrogen. This effect was also seen in human liver cells and endothelial cells. Additionally, ML 221 has been shown to inhibit mitochondrial membrane potential and endothelial cell proliferation. Finally, ML 221 has been shown to decrease the severity of proliferative diabetic retinopathy (PDR) by blocking FGF receptors on blood vessels that line the retina.
ML 221 is an experimental drug that inhibits follicular growth and can be used to treat PDR.

Formel: C₁₇H₁₁N₃O₆S

Reinheit: Min. 95%

Molekulargewicht: 385.35 g/mol

Ref: 3D-CKB63642