CAS 88937-61-5

Z-Arg-Arg-AMC

Beschreibung:

Z-Arg-Arg-AMC, auch bekannt unter seiner CAS-Nummer 88937-61-5, ist ein synthetisches Peptidsubstrat, das häufig in der biochemischen Forschung verwendet wird, insbesondere in Studien, die Proteasen und enzymatische Aktivität betreffen. Diese Verbindung weist eine Z (Benzyloxycarbonyl)-Schutzgruppe am N-terminalen Argininrest auf, was ihre Stabilität und Löslichkeit verbessert. Die Anwesenheit von zwei Argininresten in ihrer Struktur macht sie zu einem Substrat für verschiedene Enzyme, insbesondere für solche, die an basischen Aminosäuren spalten. Die AMC (7-Amino-4-methylcoumarin)-Einheit dient als fluoreszierender Reporter, der die Quantifizierung der enzymatischen Aktivität durch Fluoreszenzmessungen ermöglicht. Z-Arg-Arg-AMC wird häufig in Assays verwendet, um die proteolytische Aktivität zu untersuchen, und liefert Einblicke in die Enzymkinetik und die Substratspezifität. Zu den Eigenschaften gehören eine hohe Löslichkeit in wässrigen Lösungen, Stabilität unter physiologischen Bedingungen und die Fähigkeit, ein messbares fluoreszierendes Signal nach der Spaltung zu erzeugen, was es zu einem wertvollen Werkzeug in der molekularbiologischen und biochemischen Forschung macht.

Formel: C₃₀H₃₉N₉O₆

InChl: InChI=1/C30H39N9O6/c1-18-15-25(40)45-24-16-20(11-12-21(18)24)37-22(9-5-13-35-28(31)32)26(41)39-27(42)23(10-6-14-36-29(33)34)38-30(43)44-17-19-7-3-2-4-8-19/h2-4,7-8,11-12,15-16,22-23,37H,5-6,9-10,13-14,17H2,1H3,(H,38,43)(H4,31,32,35)(H4,33,34,36)(H,39,41,42)/t22-,23-/m0/s1

InChI Key: InChIKey=DLELKZFCVLJXKZ-GOTSBHOMSA-N

SMILES: CC=1C=2C(=CC(NC([C@@H](NC([C@@H](NC(OCC3=CC=CC=C3)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=CC2)OC(=O)C1

Synonyme:

• Z-Arg-Arg-AMC
• Benzyloxycarbonyl-L-arginyl-L-arginine 4-methylcoumaryl-7-amide
• 386: PN: US20220178935 SEQID: 1064 claimed sequence
• N2-[(Phenylmethoxy)carbonyl]-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-argininamide
• L-Argininamide, N2-[(phenylmethoxy)carbonyl]-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• Z-Arg-Arg-NHMec
• Z-ARG-ARG-MCA(HYDROCHLORIDE FORM)
• Z-ARG-ARG-MCA HYDROCHLORIDE
• BENZYLOXYCARBONYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE HYDROCHLORIDE
• benzyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-2-[(4-methyl-2-oxochromen-7-yl)amino]pentanoyl]amino]-1-oxopentan-2-yl]carbamate
• N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
• Z-ARG-ARG-AMC HYDROCHLORIDE SALT
• benzyloxycarbonylarginyl-arginine 4-methylcoumarin-7-ylamide

Z-Arg-Arg-AMC

CAS: 88937-61-5

Z-RR-AMC, an excellent, specific substrate for cathepsin B, an enzyme found in secretory vesicles. Cathepsin B has been identified as a β-secretase, as such it is involved in β-amyloid production. Z-RR-AMC is a convenient fluorogenic substrate for stem bromelain, as it is scarcely affected by fruit bromelain.

Formel: C₃₀H₃₉N₉O₆

Reinheit: > 98%

Farbe und Form: White Powder

Molekulargewicht: 621.7

Ref: 01-4004789

Z-Arg-Arg-AMC hydrochloride salt

CAS: 88937-61-5

Z-Arg-Arg-AMC hydrochloride salt is a versatile compound that acts as a catalyst and forms strong hydrogen bonds. It exhibits proteolytic activity and has been found to be effective in breaking down proteins. In addition, Z-Arg-Arg-AMC hydrochloride salt has been shown to possess neuroprotective properties, making it a potential candidate for the treatment of neurological disorders. It also demonstrates anthelmintic activity, which means it can be used to combat parasitic worm infections. Furthermore, this compound has antioxidant activity and can help reduce lipid peroxidation, protecting cells from oxidative damage. With its diverse range of characteristics, Z-Arg-Arg-AMC hydrochloride salt holds great promise in various research fields such as biochemistry and medicine.

Formel: C₃₀H₃₉N₉O₆·xHCl

Reinheit: Min. 95%

Farbe und Form: Powder

Molekulargewicht: 621.69 g/mol

Ref: 3D-FA110491

Z-Arg-Arg-AMC

CAS: 88937-61-5

Z-Arg-Arg-AMC is an activator of the receptor tyrosine kinase (RTK) system. It binds to the extracellular domain of RTKs, such as epidermal growth factor receptors (EGFR) and fibroblast growth factor receptors (FGFR), and activates these receptors. This compound has been shown to activate EGFR and FGFR at low concentrations and inhibit their activation at high concentrations. Z-Arg-Arg-AMC has also been shown to be a potent inhibitor of protein interactions with a Kd of approximately 1 μM, which makes it a useful research tool for studying protein interactions.

Formel: C₃₀H₃₉N₉O₆

Reinheit: Min. 95%

Molekulargewicht: 621.69 g/mol

Ref: 3D-MRR-3123-V