CAS 89-25-8

Edaravon

Beschreibung:

Edaravon, mit der CAS-Nummer 89-25-8, ist eine synthetische Verbindung, die hauptsächlich für ihre neuroprotektiven Eigenschaften anerkannt ist. Sie wird als Radikalfänger klassifiziert, was bedeutet, dass sie schädliche freie Radikale im Körper neutralisieren kann, wodurch der oxidative Stress verringert wird. Diese Eigenschaft macht sie besonders relevant für die Behandlung neurodegenerativer Erkrankungen wie amyotrophe Lateralsklerose (ALS) und akuten ischämischen Schlaganfall. Edaravon wird typischerweise als farblose bis blassgelbe Flüssigkeit präsentiert und ist in Wasser löslich, was die Verabreichung in klinischen Umgebungen erleichtert. Die Verbindung hat ein relativ niedriges Molekulargewicht und zeigt ein moderates Maß an Lipophilie, was es ihr ermöglicht, biologischen Membranen effektiv zu durchdringen. Ihr Wirkmechanismus umfasst die Hemmung der Lipidperoxidation und den Schutz von Nervenzellen vor oxidativen Schäden. Edaravon wurde umfassend auf sein therapeutisches Potenzial untersucht, und obwohl es im Allgemeinen gut vertragen wird, kann es Nebenwirkungen haben, die während der Behandlung überwacht werden müssen.

Formel: C₁₀H₁₀N₂O

InChl: InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3

InChI Key: InChIKey=QELUYTUMUWHWMC-UHFFFAOYSA-N

SMILES: O=C1N(N=C(C)C1)C2=CC=CC=C2

Synonyme:

• 1,3,5-Pmp
• 1-Fenil-3-Metil-5-Pirazolona
• 1-Phenyl-3-Methyl-5-Prazalone
• 1-Phenyl-3-Methyl-5-Pyrazole
• 1-Phenyl-3-Methyl-5-Pyrazolone
• 1-Phenyl-3-methyl-1H-4,5-dihydropyrazol-5-one
• 1-Phenyl-3-methyl-2-pyrazolin-5-one
• 1-Phenyl-3-methyl-5-oxopyrazole
• 1-Phenyl-3-methyl-5-pyrazolinone
• 2,4-Dihydro-5-Methyl-2-Phenyl-3H-Pyrazol-3-On
• 2,4-Dihydro-5-Methyl-2-Phenyl-3H-Pyrazol-3-One
• 2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazole-3-one
• 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
• 3-Methyl-1-phenyl-1H-pyrazol-5(4H)-one
• 3-Methyl-1-phenyl-1H-pyrazol-5-one
• 3-Methyl-1-phenyl-2-pyrazoline-5-one
• 3-Methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one
• 3-Methyl-1-phenyl-4,5-dihydropyrazol-5-one
• 3-Methyl-1-phenyl-4,5-dihydropyrazole-5-one
• 3-Methyl-1-phenyl-5-pyrazolon
• 3-Methyl-1-phenyl-5-pyrazolone
• 3-Methyl-1-phenylpyrazol-5(4H)-one
• 3-Methyl-1-phenylpyrazol-5-one
• 3-Methyl-1-phenylpyrazole-5-one
• 3-Methyl-1-phenylpyrazolin-5-one
• 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
• 4,5-Dihydro-3-methyl-5-oxo-1-phenylpyrazole
• 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
• 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
• 5-Methyl-2-phenyl-2,4-dihydropyrazol-3-one
• 5-Methyl-2-phenyl-2H-pyrazol-3(4H)-one
• 5-Methyl-2-phenylpyrazol-3-one
• Developer Z
• Edarabone
• Edaravon
• Edaravone
• Edvaradone
• Mci-186
• Methylphenylpyrazolone
• Nci-C 03952
• Norantipyrine
• Norphenazone
• Nsc 12
• Nsc 26139
• Nsc 2629
• PMP
• Phenylmethyl pyrazolone
• Pyrazolin(2)-5-One, 3-Methyl-1-Phenyl-
• Radicava
• Radicut
• C.I. Developer 1

3-Methyl-1-phenyl-5-pyrazolone

CAS: 89-25-8

Formel: C₁₀H₁₀N₂O

Reinheit: >98.0%(T)(HPLC)

Farbe und Form: White to Orange to Green powder to crystal

Molekulargewicht: 174.20

Ref: 3B-M0687

3-Methyl-1-phenyl-2-pyrazolin-5-one, 98+%

CAS: 89-25-8

3-Methyl-1-phenyl-2-pyrazolin-5-one used as reagent for detection of reducing carbohydrates by ESI/MALDI -MS. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original A

Formel: C₁₀H₁₀N₂O

Reinheit: 98+%

Farbe und Form: Pale cream to cream to yellow to pale brown, Powder

Molekulargewicht: 174.20

Ref: 02-A11161

PHENAZONE IMPURITY A CRS

CAS: 89-25-8

PHENAZONE IMPURITY A CRS

Ref: 41-Y0001138

Antipyrine Related Compound A (3-Methyl-1-phenyl-1H-pyrazol-5(4H)-one)

CAS: 89-25-8

Aromatic or modified aromatic compounds containg an unfused pyrazolering (whether or not hydrogenated) in the structure

Formel: C₁₀H₁₀N₂O

Farbe und Form: White Pale Yellow Powder

Molekulargewicht: 174.07931

Ref: 45-1040016

Edaravone

CAS: 89-25-8

Edaravone (MCI-186)(MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.

Formel: C₁₀H₁₀N₂O

Reinheit: 99.44% - >99.99%

Farbe und Form: Pale Yellow Solid Solid Particulate/Powder

Molekulargewicht: 174.20

Ref: TM-T0407

Edaravone

CAS: 89-25-8

Formel: C₁₀H₁₀N₂O

Reinheit: 95%

Farbe und Form: Solid

Molekulargewicht: 174.1992

Ref: IN-DA0087X2

Edaravone

CAS: 89-25-8

Formel: C₁₀H₁₀N₂O

Farbe und Form: White To Off-White Solid

Molekulargewicht: 174.20

Ref: 4Z-E-531

Edaravone

CAS: 89-25-8

Edaravone

Reinheit: ≥98%

Molekulargewicht: 174.2g/mol

Ref: 54-BUP18301

1-Phenyl-3-methyl-5-pyrazolone

CAS: 89-25-8

1-Phenyl-3-methyl-5-pyrazolone

Formel: C₁₀H₁₀N₂O

Reinheit: 98%

Farbe und Form: yellow crystalline powder

Molekulargewicht: 174.20g/mol

Ref: 54-BIP1205

1-Phenyl-3-methyl-5-pyrazolone

CAS: 89-25-8

Formel: C₁₀H₁₀N₂O

Reinheit: ≥ 98.0%

Farbe und Form: White to yellow to brown powder or crystals

Molekulargewicht: 174.20

Ref: 7W-GK3502

5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (Edaravone)

CAS: 89-25-8

Formel: C₁₀H₁₀N₂O

Farbe und Form: Neat

Molekulargewicht: 174.20

Ref: 86-MM0036.01

Edaravone

CAS: 89-25-8

Formel: C₁₀H₁₀N₂O

Farbe und Form: Neat

Molekulargewicht: 174.20

Ref: 04-C13105000

3-​Methyl-​1-​phenyl-​2-​pyrazolin-​5-​one(Edaravone)

Kontrolliertes Produkt

CAS: 89-25-8

Impurity Phenazone EP Impurity A
Applications Edaravone inhibits the disease activity in rheumatoid arthritis. Edaravone can significantly enhance IR flap viability and protect flap vessels, which is related to scavenging oxygen free radicals, reducing the consumption of SOD, reducing the extent of lipid peroxidation and inflammation, and protecting functional structure of vessels in the early stages of reperfusion. It also shows protective effects against STZ-induced cognitive impairment, oxidative stress, cholinergic dysfunction and altered protein expressions. Its acts like a free radical scavenger, decreased apoptotic cell death, oxidative damage to DNA and lipids, and angiogenesis through inhibiting JNK and p38 MAPK pathways in AMD, glaucoma, DR, and RVO animal models.
References Reeta KH et al. Eur J Neurosci. 2017 Feb 15Masuda T et al. Oxid Med Cell Longev. 2017;2017:9208489Zhang DY et al. J Huazhong Univ Sci Technolog Med Sci. 2017 Feb;37(1):51-56Criswell LA et al. Am J Med. 2002 Apr 15;112(6):465-71.

Formel: C₁₀H₁₀N₂O

Farbe und Form: Neat

Molekulargewicht: 174.20

Ref: TR-E335000

Antipyrine USP Related Compound A

CAS: 89-25-8

Formel: C₁₀H₁₀N₂O

Molekulargewicht: 174.2

Ref: ST-EA-CP-A104005

3-Methyl-1-phenyl-2-pyrazoline-5-one

CAS: 89-25-8

Formel: C₁₀H₁₀N₂O

Reinheit: 95%

Farbe und Form: Solid

Molekulargewicht: 174.203

Ref: 10-F038216

Edaravone

CAS: 89-25-8

Edaravone is a drug that belongs to the class of radical scavengers and has been shown to be effective in reducing neuronal death by blocking the mitochondrial permeability transition pore. It also protects against oxidative injury by inhibiting lipid peroxidation, protein nitration, and DNA damage. Edaravone has been shown to be effective in treating bowel disease and possibly other inflammatory diseases such as sepsis. Edaravone is injected intravenously and can be used as an injection solution with dextran sulfate due to its low solubility in water. Edaravone binds reversibly to the toll-like receptor 4 (TLR4) and inhibits TLR4-mediated signaling pathways, which may lead to a reduction of inflammation.

Formel: C₁₀H₁₀N₂O

Reinheit: Min. 98%

Farbe und Form: Powder

Molekulargewicht: 174.2 g/mol

Ref: 3D-FE22642

Edaravone

CAS: 89-25-8

Aromatic or modified aromatic compounds containg an unfused pyrazolering (whether or not hydrogenated) in the structure

Formel: C₁₀H₁₀N₂O

Molekulargewicht: 174.07931

Ref: 45-1231900