CAS 90954-53-3

menschliches Calcitonin-Gen-bezogenes Peptid

Beschreibung:

Das calcitonin-genverwandte Peptid (CGRP) ist ein Neuropeptid, das eine bedeutende Rolle in verschiedenen physiologischen Prozessen spielt, insbesondere im Nervensystem und in der kardiovaskulären Regulation. Es stammt vom Calcitonin-Gen ab und ist hauptsächlich an der Vasodilatation und der Übertragung von Schmerzsignalen beteiligt. CGRP besteht aus einer Sequenz von Aminosäuren, was es zu einem Peptid macht, und es existiert in zwei Isoformen: Alpha und Beta, wobei die Alpha-Form bei Menschen vorherrschend ist. Das Peptid ist bekannt für seine starken vasodilatatorischen Effekte, die zu seiner Rolle in der Migräne-Pathophysiologie beitragen. CGRP ist auch an entzündlichen Reaktionen beteiligt und wurde auf seine potenziellen therapeutischen Anwendungen bei Erkrankungen wie Migräne und anderen Schmerzstörungen untersucht. Seine biologische Aktivität wird über spezifische Rezeptoren vermittelt, die als CGRP-Rezeptoren bekannt sind und G-Protein-gekoppelte Rezeptoren sind. Die CAS-Nummer 90954-53-3 identifiziert diese Substanz eindeutig in chemischen Datenbanken und erleichtert die Forschung und Entwicklung in der Pharmakologie und Biochemie.

Formel: C₁₆₃H₂₆₇N₅₁O₄₉S₂

InChl: InChI=1/C163H269N51O49S2/c1-73(2)52-97(186-116(226)65-179-131(233)82(18)183-139(241)98(53-74(3)4)193-137(239)94(44-35-49-176-162(171)172)188-142(244)101(57-91-62-175-72-182-91)199-159(261)128(88(24)221)213-156(258)123(79(13)14)207-151(253)110(71-265)204-160(262)126(86(22)219)210-133(235)84(20)185-157(259)125(85(21)218)211-147(249)105(61-119(229)230)198-150(252)109(70-264)203-130(232)81(17)166)140(242)194-99(54-75(5)6)141(243)202-108(69-217)149(251)190-95(45-36-50-177-163(173)174)138(240)201-106(67-215)134(236)180-63-115(225)178-64-118(228)205-121(77(9)10)155(257)208-122(78(11)12)154(256)191-93(43-32-34-48-165)136(238)196-102(58-112(167)222)144(246)197-103(59-113(168)223)143(245)195-100(56-90-40-29-26-30-41-90)145(247)209-124(80(15)16)161(263)214-51-37-46-111(214)152(254)212-127(87(23)220)158(260)200-104(60-114(169)224)146(248)206-120(76(7)8)153(255)181-66-117(227)187-107(68-216)148(250)189-92(42-31-33-47-164)135(237)184-83(19)132(234)192-96(129(170)231)55-89-38-27-25-28-39-89/h25-30,38-41,62,72-88,92-111,120-128,215-221,264-265H,31-37,42-61,63-71,164-166H2,1-24H3,(H2,167,222)(H2,168,223)(H2,169,224)(H2,170,231)(H,175,182)(H,178,225)(H,179,233)(H,180,236)(H,181,255)(H,183,241)(H,184,237)(H,185,259)(H,186,226)(H,187,227)(H,188,244)(H,189,250)(H,190,251)(H,191,256)(H,192,234)(H,193,239)(H,194,242)(H,195,245)(H,196,238)(H,197,246)(H,198,252)(H,199,261)(H,200,260)(H,201,240)(H,202,243)(H,203,232)(H,204,262)(H,205,228)(H,206,248)(H,207,253)(H,208,257)(H,209,247)(H,210,235)(H,211,249)(H,212,254)(H,213,258)(H,229,230)(H4,171,172,176)(H4,173,174,177)/t81-,82-,83-,84-,85+,86+,87+,88+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-,124-,125-,126-,127-,128-/m0/s1

Synonyme:

• Calcitonin Gene-Related Peptide-I, Human
• Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-Nh2

Calcitonin Gene Related Peptide, Human

CAS: 90954-53-3

For cellular and molecular biology applications

Formel: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Molekulargewicht: 3789.3

Ref: 02-J65667

α-CGRP (human)

CAS: 90954-53-3

Bachem ID: 4013281.

Formel: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Reinheit: 97.62%

Farbe und Form: White

Molekulargewicht: 3789.36

Ref: 01-4013281

α-CGRP(human)

CAS: 90954-53-3

Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.

Formel: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 3789.33

Ref: TM-TP2044

CGRP (Human)

CAS: 90954-53-3

Human CGRP with a disulfide bond between Cys2-Cys7 and available as a 0.1mg vial. CGRP (calcitonin gene-related peptide) is a 37-amino acid neuropeptide that is found in humans and is widely distributed in the nervous system, particularly in sensory neurons, and is involved in the regulation of vascular tone, blood flow, pain perception, and inflammation. It is a potent vasodilator and has been implicated in the pathophysiology of several vascular disorders, including migraine headaches, cluster headaches, and hypertension.
In addition to its vascular effects, human CGRP also has neuroprotective properties and has been investigated as a potential therapeutic agent for various neurological disorders, such as Alzheimer's disease and Parkinson's disease.
Human CGRP has been extensively studied as a research tool to investigate its physiological and pathological roles in various tissues and diseases. It has also been targeted by pharmacological agents, such as CGRP antagonists and antibodies, for the treatment of migraine headaches and other conditions associated with CGRP dysfunction.

Formel: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Reinheit: Min. 95%

Molekulargewicht: 3,789.3 g/mol

Ref: 3D-PCG-4160-S

CGRP (Human)

CAS: 90954-53-3

CGRP (calcitonin gene-related peptide) is a 37-amino acid neuropeptide that is found in humans and is widely distributed in the nervous system, particularly in sensory neurons, and is involved in the regulation of vascular tone, blood flow, pain perception, and inflammation. It is a potent vasodilator and has been implicated in the pathophysiology of several vascular disorders, including migraine headaches, cluster headaches, and hypertension.
In addition to its vascular effects, human CGRP also has neuroprotective properties and has been investigated as a potential therapeutic agent for various neurological disorders, such as Alzheimer's disease and Parkinson's disease.
Human CGRP has been extensively studied as a research tool to investigate its physiological and pathological roles in various tissues and diseases. It has also been targeted by pharmacological agents, such as CGRP antagonists and antibodies, for the treatment of migraine headaches and other conditions associated with CGRP dysfunction.
This product is available as a 0.5mg vial.

Formel: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Reinheit: Min. 95%

Molekulargewicht: 3,789.3 g/mol

Ref: 3D-PCG-4160-V