CAS 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC

Beschreibung:

Suc-Leu-Leu-Val-Tyr-AMC, auch bekannt als Peptidsubstrat, ist eine synthetische Verbindung, die aus einer Sequenz von Aminosäuren besteht: succinyliertes Leucin, Leucin, Valin, Tyrosin und 7-Amido-4-methylcoumarin (AMC). Diese Verbindung wird hauptsächlich in biochemischen Assays verwendet, um proteolytische Enzyme zu untersuchen, insbesondere solche, die Peptidbindungen spalten. Die Succinylgruppe verbessert die Löslichkeit und Stabilität des Peptids, während die AMC-Einheit als fluoreszierender Reporter dient, der die Detektion der enzymatischen Aktivität durch Fluoreszenzmessungen ermöglicht. Die Eigenschaften dieser Substanz umfassen ihre Fähigkeit, durch spezifische Proteasen hydrolysiert zu werden, was zur Freisetzung von AMC führt, das quantitativ gemessen werden kann. Diese Eigenschaft macht sie wertvoll für Forschungsanwendungen, insbesondere in den Bereichen Enzymologie und Arzneimittelentdeckung. Darüber hinaus trägt die Struktur von Suc-Leu-Leu-Val-Tyr-AMC zu ihrer Spezifität für bestimmte Enzyme bei, was sie zu einem nützlichen Werkzeug für das Studium der Enzymkinetik und Hemmung macht.

Formel: C₄₀H₅₃N₅O₁₀

InChl: InChI=1/C40H53N5O10/c1-21(2)16-29(42-33(47)14-15-34(48)49)38(52)43-30(17-22(3)4)39(53)45-36(23(5)6)40(54)44-31(19-25-8-11-27(46)12-9-25)37(51)41-26-10-13-28-24(7)18-35(50)55-32(28)20-26/h8-13,18,20-23,29-31,36,46H,14-17,19H2,1-7H3,(H,41,51)(H,42,47)(H,43,52)(H,44,54)(H,45,53)(H,48,49)/t29?,30?,31-,36-/m0/s1

SMILES: CC(C)CC(C(=NC(CC(C)C)C(=N[C@@H](C(C)C)C(=N[C@@H](Cc1ccc(cc1)O)C(=Nc1ccc2c(C)cc(=O)oc2c1)O)O)O)O)N=C(CCC(=O)O)O

Synonyme:

• N-succinyl-leu-leu-val-tyr 7-amido-4-*methylcouma
• Succinyl-leucyl-leucyl-valyl-tyrosyl-methylcoumarinamide
• Llvy-mca
• N-Succinyl-leu-leu-val-tyr-7-amido-4-methylcoumarin
• Sllvt-mca
• Suc-leu-leu-val-tyr-7-amino-4-methylcoumarin
• Suc-leu-leu-val-tyr-mca
• Suc-llvy-mca
• L-Tyrosinamide, N-(3-carboxy-1-oxopropyl)-L-leucyl-L-leucyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• N-(3-carboxypropanoyl)leucylleucyl-L-valyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-tyrosinamide

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

The fluorogenic substrate Suc-LLVY-AMC is used for measuring the chymotrypsin-like activity of the 20S proteasome, in combination with e.g. Bz-VGR-AMC (for assaying its trypsin-like activity) and Z-LLE-AMC (for determining its PGPH activity). Suc-LLVY-AMC is also cleaved by a chymotrypsin-like enzyme from sperm extract of the ascidian Halocynthia roretzi, a strong inhibitor of fertilization. The substrate has also been used to analyze the chymotrypsin-like activity of trypsins as well as chymase from rat mast cells. Furthermore, Suc-LLVY-AMC is a substrate for carboxypeptidase Y, proteinase yscE (kexin), ingensin, as well as for porcine calpain isozymes I and II and for papain.

Formel: C₄₀H₅₃N₅O₁₀

Reinheit: > 98%

Farbe und Form: White

Molekulargewicht: 763.89

Ref: 01-4011369

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Formel: C₄₀H₅₃N₅O₁₀

Reinheit: 95%

Farbe und Form: Solid

Molekulargewicht: 763.8763

Ref: IN-DA01E5Y8

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC is a fluorescent substrate for the 20S proteasome, other chymotrypsin-like proteases.

Formel: C₄₀H₅₃N₅O₁₀

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 763.88

Ref: TM-TP1308

N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin

CAS: 94367-21-2

Formel: C₄₀H₅₃N₅O₁₀

Reinheit: ≥ 95.0%

Farbe und Form: White to off-white powder

Molekulargewicht: 763.89

Ref: 7W-GL1880

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC is a peptide that is an activator of ion channels. It can be used to study the effects of ion channel activation on various cells and tissues. Suc-Leu-Leu-Val-Tyr-AMC has also been shown to inhibit ligand binding to some receptors, such as the acetylcholine receptor. This peptide can also be used as a research tool for pharmacology, protein interactions, and antibody production.

Formel: C₄₀H₅₃N₅O₁₀

Reinheit: Min. 95%

Molekulargewicht: 763.88 g/mol

Ref: 3D-MLL-3120-V

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC is a cyclin D2 inhibitor that binds to the proteasome and inhibits its function. It has been shown to be useful for the treatment of cancerous tissues as it inhibits the production of prostaglandin J2, which is involved in the progression of cancer cells. Suc-Leu-Leu-Val-Tyr-AMC has also been shown to have antioxidant properties and can inhibit oxidative injury. This drug may be used to prevent or treat various diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, diabetes mellitus type II, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and septic shock.

Formel: C₄₀H₅₃N₅O₁₀

Reinheit: Min. 95%

Farbe und Form: Powder

Molekulargewicht: 763.88 g/mol

Ref: 3D-FS110535