CAS 957230-65-8

Isofagomine D-Tartrate

CAS: 957230-65-8

Formel: C₆H₁₃NO₃·C₄H₆O₆

Molekulargewicht: 147.17 150.09

Ref: 4Z-F-103003

Isofagomine D-Tartrate

CAS: 957230-65-8

Stability Very Hygroscopic
Applications Used as human acid β-glucosidase inhibitor and for the treatment of Gaucher disease.
References Zhou, Z., et al.: J. Biol. Chem., 274, 31123 (1999), Pandey, G., et al.: Tetrahedron lett., 41, 8821, (2000).

Formel: C₆H₁₃NO₃·C₄H₆O₆

Farbe und Form: Neat

Molekulargewicht: 297.26

Ref: TR-I816010

Isofagomine D-tartrate

CAS: 957230-65-8

Inhibitor of lysosomal acid β-glucosidase (GlcCerase/glucocerebrosidase) with IC50 in nanomolar range for wildtype and mutant enzyme. It behaves as pharmacological chaperon by binding to instable GlcCerase active site at neutral pH values and facilitating the protein folding. In acidic lysosomes, isofagomine gets release from the enzyme active site. This results in increased levels of functional glucocerebrosidase and brings therapeutic benefits to patients with Gaucher disease.

Formel: C₁₀H₁₉NO₉

Reinheit: Min. 95%

Farbe und Form: White Powder

Molekulargewicht: 297.26 g/mol

Ref: 3D-MI24675

Afegostat D-Tartrate

CAS: 957230-65-8

Afegostat D-Tartrate: pharmacological chaperone, reversibly binds acid-β-glucosidase in ER with high affinity.

Formel: C₁₀H₁₉NO₉

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 297.26

Ref: TM-T19182