CAS 99294-94-7

Teriparatidacetat-Hydrat

Beschreibung:

Teriparatidacetat-Hydrat ist ein synthetisches Peptid, das die Wirkung des Parathormons (PTH) nachahmt und hauptsächlich zur Behandlung von Osteoporose eingesetzt wird. Es zeichnet sich durch seine Fähigkeit aus, die Knochenbildung zu stimulieren, indem es die Aktivität der Osteoblasten fördert, was es besonders effektiv macht, um die Knochendichte zu erhöhen und das Risiko von Frakturen bei postmenopausalen Frauen und Personen mit bestimmten Arten von Osteoporose zu verringern. Die Substanz wird typischerweise durch subkutane Injektion verabreicht und ist bekannt für ihre relativ kurze Halbwertszeit, die tägliche Dosen erforderlich macht. Teriparatidacetat-Hydrat ist ein weißes bis off-white Pulver, das in Wasser löslich ist, und seine Formulierung enthält Acetat als Gegenion, was hilft, das Peptid zu stabilisieren. Die molekulare Struktur der Verbindung besteht aus 34 Aminosäuren und wird aufgrund ihrer peptidischen Natur als biologisches Arzneimittel eingestuft. Wie bei jedem Medikament ist es wichtig, mögliche Nebenwirkungen, Kontraindikationen und die Notwendigkeit einer Überwachung während der Behandlung zu berücksichtigen.

Formel: C₂H₄O₂·xH₂O·xUnspecified

InChl: InChI=1/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199)

SMILES: CCC(C)C(C(=NC(CCC(=N)O)C(=NC(CC(C)C)C(=NC(CCSC)C(=NC(Cc1cnc[nH]1)C(=NC(CC(=N)O)C(=NC(CC(C)C)C(=NCC(=NC(CCCCN)C(=NC(Cc1cnc[nH]1)C(=NC(CC(C)C)C(=NC(CC(=N)O)C(=NC(CO)C(=NC(CCSC)C(=NC(CCC(=O)O)C(=NC(CCCNC(=N)N)C(=NC(C(C)C)C(=NC(CCC(=O)O)C(=NC(Cc1c[nH]c2ccccc12)C(=NC(CC(C)C)C(=NC(CCCNC(=N)N)C(=NC(CCCCN)C(=NC(CCCCN)C(=NC(CC(C)C)C(=NC(CCC(=N)O)C(=NC(CC(=O)O)C(=NC(C(C)C)C(=NC(Cc1cnc[nH]1)C(=NC(CC(=N)O)C(=NC(Cc1ccccc1)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(C(CCC(=O)O)N=C(C(CO)N=C(C(C(C)C)N=C(C(CO)N)O)O)O)O

Synonyme:

• <span class="text-smallcaps">L</smallcap>-Phenylalanine, <smallcap>L</smallcap>-seryl-<smallcap>L</smallcap>-valyl-<smallcap>L</smallcap>-seryl-<smallcap>L</smallcap>-α-glutamyl-<smallcap>L</smallcap>-isoleucyl-<smallcap>L</smallcap>-glutaminyl-<smallcap>L</smallcap>-leucyl-<smallcap>L</smallcap>-methionyl-<smallcap>L</smallcap>-histidyl-<smallcap>L</smallcap>-asparaginyl-<smallcap>L</smallcap>-leucylglycyl-<smallcap>L</smallcap>-lysyl-<smallcap>L</smallcap>-histidyl-<smallcap>L</smallcap>-leucyl-<smallcap>L</smallcap>-asparaginyl-<smallcap>L</smallcap>-seryl-<smallcap>L</smallcap>-methionyl-<smallcap>L</smallcap>-α-glutamyl-<smallcap>L</smallcap>-arginyl-<smallcap>L</smallcap>-valyl-<smallcap>L</smallcap>-α-glutamyl-<smallcap>L</smallcap>-tryptophyl-<smallcap>L</smallcap>-leucyl-<smallcap>L</smallcap>-arginyl-<smallcap>L</smallcap>-lysyl-<smallcap>L</smallcap>-lysyl-<smallcap>L</smallcap>-leucyl-<smallcap>L</smallcap>-glutaminyl-<smallcap>L</smallcap>-α-aspartyl-<smallcap>L</smallcap>-valyl-<smallcap>L</smallcap>-histidyl-<smallcap>L</span>-asparaginyl-, acetate (salt), hydrate
• <span class="text-smallcaps">L</smallcap>-Phenylalanine, <smallcap>L</smallcap>-seryl-<smallcap>L</smallcap>-valyl-<smallcap>L</smallcap>-seryl-<smallcap>L</smallcap>-α-glutamyl-<smallcap>L</smallcap>-isoleucyl-<smallcap>L</smallcap>-glutaminyl-<smallcap>L</smallcap>-leucyl-<smallcap>L</smallcap>-methionyl-<smallcap>L</smallcap>-histidyl-<smallcap>L</smallcap>-asparaginyl-<smallcap>L</smallcap>-leucylglycyl-<smallcap>L</smallcap>-lysyl-<smallcap>L</smallcap>-histidyl-<smallcap>L</smallcap>-leucyl-<smallcap>L</smallcap>-asparaginyl-<smallcap>L</smallcap>-seryl-<smallcap>L</smallcap>-methionyl-<smallcap>L</smallcap>-α-glutamyl-<smallcap>L</smallcap>-arginyl-<smallcap>L</smallcap>-valyl-<smallcap>L</smallcap>-α-glutamyl-<smallcap>L</smallcap>-tryptophyl-<smallcap>L</smallcap>-leucyl-<smallcap>L</smallcap>-arginyl-<smallcap>L</smallcap>-lysyl-<smallcap>L</smallcap>-lysyl-<smallcap>L</smallcap>-leucyl-<smallcap>L</smallcap>-glutaminyl-<smallcap>L</smallcap>-α-aspartyl-<smallcap>L</smallcap>-valyl-<smallcap>L</smallcap>-histidyl-<smallcap>L</span>-asparaginyl-, acetate, hydrate (1:?:?)
• Forteo
• L-Phenylalanine, L-seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-, acetate (salt)
• L-Phenylalanine, L-seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-, acetate (salt) hydrate
• L-Seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-L-phenylalanine acetate (salt) hydrate
• Parathar
• Parathar acetate
• Teribone
• Teriparatide Acetate
• Teriparatide acetate hydrate
• L-Phenylalanine, L-seryl-L-valyl-L-seryl-L-α-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-α-glutamyl-L-arginyl-L-valyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-valyl-L-histidyl-L-asparaginyl-, acetate, hydrate (1:?:?)

Teriparatide Acetate

CAS: 99294-94-7

Formel: C₁₈₁H₂₉₁N₅₅O₅₁S₂·C₂H₄O₂

Reinheit: 95%~99%

Farbe und Form: White to Off-white Powder

Molekulargewicht: 4177.77

Ref: BP-BPPG062

Teriparatide acetate

CAS: 99294-94-7

Teriparatide acetate (Forteo), a synthetic parathyroid hormone, treats osteoporosis by favoring bone growth with a 2 nM IC50.

Formel: C₁₈₃H₂₉₅N₅₅O₅₃S₂

Reinheit: 99.86%

Farbe und Form: Solid

Molekulargewicht: 4177.83

Ref: TM-T21460