CAS 999-97-3

Hexamethyldisilazan

Beschreibung:

Hexamethyldisilazan (HMDS) ist eine chemische Verbindung mit der Formel (CH₃)₃Si-NH-Si(CH₃)₃. Es ist eine farblose, flüchtige Flüssigkeit mit einem charakteristischen aminartigen Geruch. HMDS wird hauptsächlich als Silyliermittel in der organischen Synthese und als Reagenz bei der Herstellung verschiedener siliziumhaltiger Verbindungen verwendet. Seine Struktur weist zwei Trimethylsilylgruppen auf, die an ein Stickstoffatom gebunden sind, was zu seiner Reaktivität und Nützlichkeit bei der Oberflächenmodifikation beiträgt, insbesondere im Bereich der Chromatographie und Materialwissenschaften. HMDS ist bekannt für seine Fähigkeit, die Stabilität und Volatilität bestimmter Verbindungen zu verbessern, was es in der analytischen Chemie wertvoll macht. Es wird auch in der Halbleiterindustrie zur Oberflächenbehandlung und Passivierung eingesetzt. Obwohl HMDS allgemein als wenig giftig gilt, sollte es aufgrund seiner Entflammbarkeit und potenziellen reizenden Eigenschaften mit Vorsicht behandelt werden. Angemessene Sicherheitsmaßnahmen, einschließlich der Verwendung persönlicher Schutzausrüstung, werden empfohlen, wenn mit dieser Substanz gearbeitet wird.

Formel: C₆H₁₉NSi₂

InChl: InChI=1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3

InChI Key: InChIKey=FFUAGWLWBBFQJT-UHFFFAOYSA-N

SMILES: N([Si](C)(C)C)[Si](C)(C)C

Synonyme:

• 1,1,1,3,3,3-Hexamethyldisilazan
• 1,1,1,3,3,3-Hexamethyldisilazane
• 1,1,1,3,3,3-Hexametildisilazano
• 1,1,1-Trimethyl-N-(trimethylsilyl)silanamine
• 12058-1A
• A 166
• A 166 (silazane)
• Bis(trimethylsilyl)amine
• Di(trimethylsilyl)amine
• Disilazane, 1,1,1,3,3,3-hexamethyl-
• Dn-L 69
• Dow Corning 4-2839
• Dynasylan HMDS
• H 0089
• HMDS (silazane)
• Hexamethyldisilazane
• Hexamethyldisilylamine
• Hexamethylsilazane
• Hmd 3
• Hmds
• Hmds 1
• Hmds 3
• Ls 7150
• Nsc 93895
• OAP
• SE 31 (silazane)
• Se 31
• Sih 6110.1
• Silazan HMN
• Sz 31
• Sz 6079
• Tsl 8802
• Tsr 8802
• Z 6079
• [Dimethyl-(trimethylsilylamino)silyl]methane
• Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-
• 1,1,1,3,3,3,-HEXAMETHYLDISILA-
• 1,1,1,3,3,3-hexamethyl-disilazan
• hexamethyldisilazane(hmds)
• 1,1,1,3,3,3-Hexamithyl disilazane
• ((CH3)3Si)2NH
• Trimethyl-N-(trimethylsilyl)silanamine
• SILAZANE HMN
• tsl8802
• hexamethyl disilizane
• LABOTEST-BB LT01408762
• 1,1,1-trimethyl-n-(trimethylsilyl)-silanamin

1,1,1,3,3,3-Hexamethyldisilazane

CAS: 999-97-3

Formel: C₆H₁₉NSi₂

Reinheit: >96.0%(GC)

Farbe und Form: Colorless to Almost colorless clear liquid

Molekulargewicht: 161.40

Ref: 3B-H0089

Hexamethyldisilazane, Electronic grade, 99+%

CAS: 999-97-3

Hexamethyldisilazane is used as a solvent in organic synthesis and organometallic chemistry. It is often used as an adhesion promoter for photoresist in photolithography. Further, it is used for the preparation of trimethylsilyl ethers from hydroxy compounds. It is used as an alternative to critical

Formel: C₆H₁₉NSi₂

Reinheit: 99+%

Farbe und Form: Clear colorless, Liquid

Molekulargewicht: 161.40

Ref: 02-L16519

Hexamethyldisilazane, 98+%

CAS: 999-97-3

Hexamethyldisilazane is used as a solvent in organic synthesis and organometallic chemistry. It is often used as an adhesion promoter for photoresist in photolithography. Further, it is used for the preparation of trimethylsilyl ethers from hydroxy compounds. It is used as an alternative to critical

Formel: C₆H₁₉NSi₂

Reinheit: 98+%

Farbe und Form: Liquid, Clear colorless to pale yellow

Molekulargewicht: 161.40

Ref: 02-A15139

Hexamethyldisilazane, min. 97%

CAS: 999-97-3

Hexamethyldisilazane, min. 97%

Formel: (CH₃)₃SiNHSi(CH₃)₃

Reinheit: min. 97%

Farbe und Form: colorless liq.

Molekulargewicht: 161.40

Ref: 08-93-1413

Hexamethyldisilazane

CAS: 999-97-3

Formel: C₆H₁₉NSi₂

Reinheit: (GC) ≥ 98.0%

Farbe und Form: Clear, colourless liquid

Molekulargewicht: 161.40

Ref: 7W-GK7882

Hexamethyldisilazane

CAS: 999-97-3

Hexamethyldisilazane

Formel: C₆H₁₉NSi₂

Reinheit: 98%

Farbe und Form: clear.colourless liquid

Molekulargewicht: 161.39275g/mol

Ref: 54-OR3890

Hexamethyldisilazane

CAS: 999-97-3

S09625 - Hexamethyldisilazane

Formel: C₆H₁₉NSi₂

Reinheit: 98%

Farbe und Form: Liquid, Clear Liquid

Molekulargewicht: 161.395

Ref: 10-S09625

Hexamethyldisilazane

CAS: 999-97-3

Formel: C₆H₁₉NSi₂

Molekulargewicht: 161.40

Ref: 4Z-S-154001

Hexamethyldisilazane

Kontrolliertes Produkt

CAS: 999-97-3

Applications Hexamethyldisilazane is used in the preparation of 5-azacytidine, an antineoplastic drug. Also used in the preparation of β3-AR agonists used in anti-stress formulations.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Vujjini, S. et al.: Org. Proc. Res. Dev., 17, 303 (2013); Xu, F. et al.: Org. Lett., 15, 1342 (2013);

Formel: C₆H₁₉NSi₂

Farbe und Form: Neat

Molekulargewicht: 161.39

Ref: TR-H296700

1,1,1,3,3,3-HEXAMETHYLDISILAZANE, 99%

CAS: 999-97-3

Alkyl Silane - Conventional Surface Bonding
Aliphatic, fluorinated aliphatic or substituted aromatic hydrocarbon substituents are the hydrophobic entities which enable silanes to induce surface hydrophobicity. The organic substitution of the silane must be non-polar. The hydrophobic effect of the organic substitution can be related to the free energy of transfer of hydrocarbon molecules from an aqueous phase to a homogeneous hydrocarbon phase. A successful hydrophobic coating must eliminate or mitigate hydrogen bonding and shield polar surfaces from interaction with water by creating a non-polar interphase. Although silane and silicone derived coatings are in general the most hydrophobic, they maintain a high degree of permeability to water vapor. This allows coatings to breathe and reduce deterioration at the coating interface associated with entrapped water. Since ions are not transported through non-polar silane and silicone coatings, they offer protection to composite structures ranging from pigmented coatings to rebar reinforced concrete. A selection guide for hydrophobic silanes can be found on pages 22-31 of the Hydrophobicity, Hydrophilicity and Silane Surface Modification brochure.
Silane Cross-Coupling Agent
The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile.
Trimethylsilyl Blocking Agent
Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.
ALD Material
Atomic layer deposition (ALD) is a chemically self-limiting deposition technique that is based on the sequential use of a gaseous chemical process. A thin film (as fine as -0.1 Å per cycle) results from repeating the deposition sequence as many times as needed to reach a certain thickness. The major characteristic of the films is the resulting conformality and the controlled deposition manner. Precursor selection is key in ALD processes, namely finding molecules which will have enough reactivity to produce the desired films yet are stable enough to be handled and safely delivered to the reaction chamber.
1,1,1,3,3,3-Hexamethyldisilazane; HMDS; HMDZ; Bis(trimethylsilyl)amine
<5 ppm chlorideStandard grade available, SIH6110.0Viscosity: 0.90 cStΔHcomb: 25,332 kJ/molΔHvap: 34.7 kJ/molDipole moment: 0.37 debyeSurface tension: 18.2 mN/mSpecific wetting surface: 485 m2/gVapor pressure, 50 °: 50 mmpKa: 7.55Photoresist adhesion promoterDielectric constant: 1000 Hz: 2.27Ea, reaction w/SiO2 surface: 73.7 kJ/molVersatile silylation reagentCreates hydrophobic surfacesConverts acid chlorides and alcohols to amines in a three-component reactionReacts with formamide and ketones to form pyrimidinesLithium reagent reacts w/ aryl chlorides or bromides to provide primary anilinesUsed to convert ketones to α-aminophosphonates

Formel: C₆H₁₉NSi₂

Reinheit: 99%

Farbe und Form: Colourless Liquid

Molekulargewicht: 161.39

Ref: 3H-SIH6110.1

1,1,1,3,3,3-HEXAMETHYLDISILAZANE, 98%

CAS: 999-97-3

Alkyl Silane - Conventional Surface Bonding
Aliphatic, fluorinated aliphatic or substituted aromatic hydrocarbon substituents are the hydrophobic entities which enable silanes to induce surface hydrophobicity. The organic substitution of the silane must be non-polar. The hydrophobic effect of the organic substitution can be related to the free energy of transfer of hydrocarbon molecules from an aqueous phase to a homogeneous hydrocarbon phase. A successful hydrophobic coating must eliminate or mitigate hydrogen bonding and shield polar surfaces from interaction with water by creating a non-polar interphase. Although silane and silicone derived coatings are in general the most hydrophobic, they maintain a high degree of permeability to water vapor. This allows coatings to breathe and reduce deterioration at the coating interface associated with entrapped water. Since ions are not transported through non-polar silane and silicone coatings, they offer protection to composite structures ranging from pigmented coatings to rebar reinforced concrete. A selection guide for hydrophobic silanes can be found on pages 22-31 of the Hydrophobicity, Hydrophilicity and Silane Surface Modification brochure.
ALD Material
Atomic layer deposition (ALD) is a chemically self-limiting deposition technique that is based on the sequential use of a gaseous chemical process. A thin film (as fine as -0.1 Å per cycle) results from repeating the deposition sequence as many times as needed to reach a certain thickness. The major characteristic of the films is the resulting conformality and the controlled deposition manner. Precursor selection is key in ALD processes, namely finding molecules which will have enough reactivity to produce the desired films yet are stable enough to be handled and safely delivered to the reaction chamber.
Trimethylsilyl Blocking Agent
Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.
Silane Cross-Coupling Agent
The cross-coupling reaction is a highly useful methodology for the formation of carbon-carbon bonds. It involves two reagents, with one typically being a suitable organometallic reagent - the nucleophile - and the other a suitable organic substrate, normally an unsaturated halide, tosylate or similar - the electrophile.
Hexamethyldisilazane; HMDS; HMDZ; Bis(trimethylsilyl)amine
Viscosity: 0.90 cStLow chloride grade available, SIH6110.1ΔHcomb: 25,332 kJ/molΔHvap: 34.7 kJ/molDipole moment: 0.37 debyeSurface tension: 18.2 mN/mSpecific wetting surface: 485 m2/gVapor pressure, 50 °C: 50 mmpKa: 7.55Dielectric constant: 1000 Hz: 2.27Ea, reaction w/SiO2 surface: 73.7 kJ/moleReleases ammonia upon reactionVersatile silylation reagentTreatment of fumed silica renders it hydrophobicBoth trimethylsilyl groups usedConverts acid chlorides and alcohols to amines in a three-component reactionReacts with formamide and ketones to form pyrimidinesSilylations catalyzed by SIT8510.0 and other reagentsNafion SAC-13 has been shown to be a recyclable catalyst for the trimethylsilylation of primary, secondary, and tertiary alcohols in excellent yields and short reaction timesUsed to convert ketones to α-aminophosphonatesLithium reagent reacts with aryl chlorides or bromides to provide anilinesSummary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochureExtensive review of silicon based cross-coupling agents: Denmark, S. E. et al. "Organic Reactions, Volume 75" Denmark, S. E. ed., John Wiley and Sons, 233, 2011

Formel: C₆H₁₉NSi₂

Reinheit: 98%

Farbe und Form: Colourless Liquid

Molekulargewicht: 161.39

Ref: 3H-SIH6110.0

1,1,1,3,3,3-Hexamethyldisilazane (HMDS) pure, 98%

CAS: 999-97-3

Formel: C₆H₁₉NSi₂

Reinheit: min. 98%

Farbe und Form: Clear, Colourless, Liquid

Molekulargewicht: 161.40

Ref: SR-28437