Kinesin
Kinesin-Inhibitoren zielen auf Kinesin-Motorproteine ab, die für den Transport von zellulärem Material entlang von Mikrotubuli verantwortlich sind und eine Schlüsselrolle bei der Zellteilung, insbesondere während der Mitose, spielen. Kinesine sind am Transport von Chromosomen und anderen Organellen während der Zellteilung beteiligt. Die Hemmung von Kinesinen kann diese Prozesse stören, was zu einem Zellzyklusarrest und möglichem Zelltod führt, wodurch diese Inhibitoren in der Krebsforschung wertvoll sind. Bei CymitQuimica bieten wir eine vielfältige Auswahl hochwertiger Kinesin-Inhibitoren zur Unterstützung Ihrer Forschung in Zellbiologie, Mitose und Krebstherapie an.
87 Produkte aus dem Bereich "Kinesin" gefunden
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Mps1-IN-3
CAS:Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).Formel:C26H31N7O4SReinheit:99.25%Farbe und Form:SolidMolekulargewicht:537.63Ref: TM-T16130
2mg34,00€5mg54,00€10mg87,00€25mg149,00€50mg255,00€100mg384,00€200mg538,00€1mL*10mM (DMSO)64,00€BOS-172722
CAS:BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).Formel:C24H30N8OReinheit:99.37%Farbe und Form:SolidMolekulargewicht:446.55Paprotrain
CAS:Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM.Formel:C16H11N3Reinheit:99.91%Farbe und Form:SolidMolekulargewicht:245.28Ref: TM-T12359
5mg46,00€10mg58,00€25mg92,00€50mg160,00€100mg236,00€200mg353,00€500mg580,00€1mL*10mM (DMSO)49,00€KIF18A-IN-2
CAS:KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities.Formel:C25H34N4O5S2Reinheit:99.64%Farbe und Form:SolidMolekulargewicht:534.69Ref: TM-T60026
1mg74,00€5mg172,00€10mg245,00€25mg383,00€50mg507,00€100mg672,00€200mg910,00€1mL*10mM (DMSO)202,00€Solidagonic acid
CAS:Solidagonic acid inhibits HSET, prevents fission yeast cell death, and hinders L. sativa and L. multiflorum seedling growth.Formel:C22H34O4Farbe und Form:SolidMolekulargewicht:362.5Anticancer agent 190
Anticancer agent 190 (compound 3e) is an inhibitor targeting KSP (Kinesin) and PI3Kδ, demonstrating efficacy against breast cancer.Formel:C21H13ClF2N2OSMolekulargewicht:414.04052CENP-E-IN-2
CENP-E-IN-2 (compound 3) is a photocontrollable CENP-E inhibitor exhibiting a pIC50 of 6.82 in the absence of light and a pIC50 of 5.85 under 365 nm light exposure. This compound also demonstrates antitumor activity.(S)-AM-9022
CAS:(S)-AM-9022 is the S-enantiomer of AM-9022, which is a potent and selective KIF18A inhibitor with oral bioavailability, applicable in cancer research.Formel:C27H36F2N6O4SFarbe und Form:SolidMolekulargewicht:578.67TTK/PLK1-IN-1
CAS:TTK/PLK1-IN-1 (Formula I) is a dual inhibitor of TTK (threonine tyrosine kinase) and PLK1 (polo-like kinase 1), with IC₅₀ values of 7 nM and 72 nM respectively.Formel:C30H33N7O2Reinheit:97.39%Farbe und Form:SolidMolekulargewicht:523.63KIF18A-IN-6
CAS:KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor that suppresses KIF18A microtubule-dependent ATPase activity with an IC50 of 0.016 μM.Formel:C28H37N3O5S2Reinheit:97.59%Farbe und Form:SolidMolekulargewicht:559.74Ref: TM-T73049
1mg69,00€5mg147,00€10mg231,00€25mg394,00€50mg522,00€100mg728,00€1mL*10mM (DMSO)177,00€Filanesib TFA
CAS:Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.
Formel:C22H23F5N4O4SReinheit:98%Farbe und Form:SolidMolekulargewicht:534.5(S)-Monastrol
CAS:Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Formel:C14H16N2O3SReinheit:98%Farbe und Form:SolidMolekulargewicht:292.35Eg5-IN-3
Eg5-IN-3 (5) is an Eg5 inhibitor targeting a novel allosteric site (α4/α6/L11). It disrupts tubulin assembly, leading to abnormal and irregular formations, which subsequently causes typical mitotic arrest, akin to the effects of Monastrol.Formel:C23H23N7O2Molekulargewicht:429.1913211H-Benzo[a]carbazole
CAS:11H-Benzo[a]carbazole is a kinesin-like protein KIF11 inhibitor that can inhibit the viability of HeLa cells.Formel:C16H11NReinheit:99.14%Farbe und Form:SolidMolekulargewicht:217.27KIF2C-IN-1
KIF2C-IN-1 (Compound 7S9) is a selective and potent small molecule inhibitor of KIF2C. It stabilizes the interaction between KIF2C and microtubule proteins, preventing the depolymerization of polyglutamylated microtubules. KIF2C-IN-1 enhances the cytotoxicity of Paclitaxel in Paclitaxel-resistant triple-negative breast cancer (TNBC) cells and, when combined with Paclitaxel, significantly reduces tumor growth in mouse models.Formel:C36H39ClN4O9SFarbe und Form:SolidMolekulargewicht:738.21263KIF18A-IN-12
CAS:KIF18A-IN-12 (compound 9), a potent KIF18A inhibitor, exhibits an IC 50 of 45.54 nM and is utilized in cancer research.Formel:C30H39F2N5O4SFarbe und Form:SolidMolekulargewicht:603.72KIF18A-IN-11
KIF18A-IN-11 (Compound 13) is an effective inhibitor of KIF18A, exhibiting IC50 values below 100 nM in OVCAR3 and MDA-MB-157 cells. It is applicable for cancer research.Formel:C28H38F2N6O4SMolekulargewicht:592.26433Mitotic kinesin-IN-3 hydrochloride
Mitotic kinesin-IN-3 (Page 135, fourteenth) hydrochloride is an inhibitor of the mitotic motor protein (Mitotickinesin). It interferes with cell proliferation by inhibiting mitosis. This compound can be utilized in research relating to cancer, cardiac hypertrophy, immune and inflammatory diseases, as well as fungal infections.Farbe und Form:Odour SolidMps1-IN-6
Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].Formel:C35H39N9O3Farbe und Form:SolidMolekulargewicht:633.74KSP ligand 1
CAS:KSP ligand 1 is a protein ligand that targets KSP (Kinesin) and can be used in the synthesis of PROTAC KSP-IN-1 for cancer research.Formel:C25H23NO3SFarbe und Form:SolidMolekulargewicht:417.52
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