PLK
PLK (Polo-like Kinase)-Inhibitoren zielen auf PLKs ab, eine Familie von Serin/Threonin-Kinasen, die für verschiedene Phasen der Zellteilung, einschließlich Mitoseeintritt, Spindelaufbau und Zytokinese, unerlässlich sind. PLKs sind entscheidend für die ordnungsgemäße Ausführung des Zellzyklus, und ihre Fehlregulation ist oft mit Krebs verbunden. Die Hemmung von PLKs kann in Krebszellen zu Zellzyklusarrest und Apoptose führen, was diese Inhibitoren zu wichtigen Werkzeugen in der Krebsforschung und -therapie macht. Bei CymitQuimica bieten wir eine Reihe hochwertiger PLK-Inhibitoren zur Unterstützung Ihrer Forschung in den Bereichen Mitose, Zellzykluskontrolle und Onkologie an.
25 Produkte aus dem Bereich "PLK" gefunden
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SP27
CAS:SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].Formel:C40H40F2N12O5Reinheit:98%Farbe und Form:SolidMolekulargewicht:806.82RP-1664
CAS:RP-1664,PLK4 inhibitor (IC50=3 nM). Disrupts centriole biogenesis. Antitumor activity in breast cancer, neuroblastoma.Formel:C23H24F2N8O2SReinheit:99.04%Farbe und Form:SoildMolekulargewicht:514.55PLK1-IN-12
PLK1-IN-12 is a highly selective, orally active PLK1 inhibitor with an IC50 of 20 nM. It demonstrates greater selectivity for PLK1 over PLK2 (IC50: >10000 nM) and PLK3 (IC50: 3953 nM). PLK1-IN-12 exhibits anticancer efficacy across a wide range of cell lines and is applicable to anti-leukemia research.Farbe und Form:Odour SolidPLK1-IN-14
PLK1-IN-14 (Compound Hit-4) is a selective PLK1 inhibitor with an IC50 of 22.61 pM for PLK1, and an IC50 of 0.09 nM for inhibiting the proliferation of DU-145 prostate cancer cells. It is applicable in prostate cancer research.Farbe und Form:Odour SolidPLK1 Protein, Mouse, Recombinant (His)
PLK1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Farbe und Form:Lyophilized PowderMolekulargewicht:70.6 kDa (predicted); 65 kDa (reducing conditions)Poloxime
CAS:Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.Formel:C10H13NO2Reinheit:98%Farbe und Form:SolidMolekulargewicht:179.22PLK1 Protein, Human, Recombinant (His)
PLK1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.Reinheit:96.8%Farbe und Form:Lyophilized PowderMolekulargewicht:70.5 kDa (predicted); 66 kDa (reducing conditions)5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
CAS:5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.Formel:C8H13N3SReinheit:99.03%Farbe und Form:SolidMolekulargewicht:183.27MLN0905
CAS:MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM).Formel:C24H25F3N6SReinheit:98% - 99.92%Farbe und Form:SolidMolekulargewicht:486.56GSK461364
CAS:GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.Formel:C27H28F3N5O2SReinheit:99% - 99.73%Farbe und Form:SolidMolekulargewicht:543.6Ref: TM-T6282
1mg34,00€2mg49,00€5mg71,00€10mg117,00€25mg195,00€50mg354,00€100mg528,00€200mg755,00€500mg1.153,00€HMN-176
CAS:HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).Formel:C20H18N2O4SReinheit:98.92% - 98.99%Farbe und Form:SolidMolekulargewicht:382.43Ref: TM-T3643
1mg40,00€2mg52,00€5mg84,00€10mg113,00€25mg178,00€50mg333,00€100mg495,00€500mg1.071,00€1mL*10mM (DMSO)74,00€(1E)-CFI-400437 dihydrochloride
CAS:(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor.Formel:C29H30Cl2N6O2Reinheit:97.08%Farbe und Form:SolidMolekulargewicht:565.5Ref: TM-T22288
1mg77,00€5mg160,00€10mg236,00€25mg394,00€50mg550,00€100mg782,00€1mL*10mM (DMSO)197,00€Poloxin
CAS:Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).Formel:C18H19NO3Reinheit:99.19%Farbe und Form:SolidMolekulargewicht:297.35HMN-214
CAS:HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.Formel:C22H20N2O5SReinheit:98% - >99.99%Farbe und Form:SolidMolekulargewicht:424.47Ref: TM-T2438
1mg38,00€2mg50,00€5mg80,00€10mg117,00€25mg207,00€50mg333,00€100mg477,00€500mg1.063,00€1mL*10mM (DMSO)87,00€TAK-960
CAS:TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.Formel:C27H34F3N7O3Reinheit:97.06%Farbe und Form:SolidMolekulargewicht:561.6Ref: TM-T7200
1mg60,00€2mg85,00€5mg114,00€10mg161,00€25mg279,00€50mg464,00€100mg672,00€1mL*10mM (DMSO)161,00€Ro3280
CAS:Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).Formel:C27H35F2N7O3Reinheit:97.1% - >99.99%Farbe und Form:SolidMolekulargewicht:543.61Centrinone-B
CAS:Centrinone-B (LCR-323) is a Plk4 inhibitor with potential anticancer activity for the study of triple-negative breast cancer.Formel:C27H27F2N7O5S2Reinheit:98.71%Farbe und Form:SolidMolekulargewicht:631.67Cyclapolin 9
CAS:Cyclapolin 9: Selective PLK1 inhibitor, IC50 500 nM, ATP-competitive, inactive against other kinases.Formel:C9H4F3N3O4SReinheit:99.64%Farbe und Form:SolidMolekulargewicht:307.21Ref: TM-T22700
1mg96,00€5mg205,00€10mg319,00€25mg512,00€50mg707,00€100mg964,00€500mg1.935,00€1mL*10mM (DMSO)227,00€Poloxin-2
CAS:Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.Formel:C16H15NO3Reinheit:99.67%Farbe und Form:SolidMolekulargewicht:269.3TC-S 7005
CAS:TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).Formel:C21H17N3O3Reinheit:99.516%Farbe und Form:SolidMolekulargewicht:359.38Ref: TM-T17008
1mg57,00€2mg84,00€5mg125,00€10mg188,00€25mg354,00€50mg532,00€100mg712,00€500mgNachfragen1mL*10mM (DMSO)138,00€
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