Chromatin/Epigenetik

Eleven-Nineteen-Leukemia Protein IN-3, an orally active ENL YEATS domain inhibitor, exhibits potent activity with an …

PIM1-IN-4 (Compound 8) is a potent PIM1 inhibitor with significant inhibitory activity against five additional …

Bromodomain Inhibitor-12 (example 303) is a research compound utilized in the study of autoimmune and …

LSD1-UM-109 is a highly potent and reversible inhibitor of LSD1, demonstrating an IC50 of 3.1 …

BChE/HDAC6-IN-1 is a dual BChE/HDAC6 inhibitor that exhibits potent and selective inhibition with IC50 values …

Eleven-Nineteen-Leukemia Protein IN-2 (compound 23), an ENL inhibitor, exhibits an IC50 of 10.7 nM and …

Compound A5b, also known as JMJD3/HDAC-IN-1, is a dual inhibitor that targets both JMJD3 (Jumonji …

SJ1461 is a potent, orally active inhibitor of the BET family, selectively targeting and inhibiting …

Antitumor agent-101 is a selective, covalent inhibitor targeting lysine methyltransferases G9a/GLP, demonstrating IC50 values of …

Compound 12C, modified by altering cap groups, exhibits broad-spectrum enzyme inhibitory activity, as demonstrated in …

YM458, a potent dual inhibitor of EZH2 and BRD4, exhibits IC50 values of 490 nM …

PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 …

BBDDL2059 is a selective covalent inhibitor targeting EZH2, exhibiting an IC50 of 1.5 nM against …

CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective …

Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an …

SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.

SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of …

(-)-Indolactam V is a PKC activator (Kis: 3.36 nM, 1.03 μM for η-CRD2 , γ-CRD2). …

Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures. Ginsenoside …

T-448 free base is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an …

RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for …

GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 …

GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, …

P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).

T-448 is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) …

KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM). KF21213 is a …

I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).

BAZ2-ICR is an epigenetic chemical probe and it also is a potent, selective, cell active …

PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)

JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM …

PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, …

GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, …

GSK8814 is a selective and ATAD2/2B bromodomain chemical probe and inhibitor (binding constant pKd=8.1 and …

JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC …

SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A …

JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus …

MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) …

Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential …

Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic …

AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent …

GSK 690 (Hydrochloride) is a reversible lysine specific demethylase 1 (LSD1) inhibitor with a Kd …

BET-IN-6, a ligand with potent and high affinity for inhibiting BRD2/BRD4, plays a crucial role …

PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for …

Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM …

The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L …

MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) …

CFT8634 is an orally active and selective degrader targeting BRD9 for the treatment of SMARCB1-perturbed …

Dehydrocrenatidine (Kumujian G) is an inhibitor of JAK and induces cell apoptosis.

GSK-J1 lithium salt is an effective inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with an IC …

GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases …

JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of …

Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter.

TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only …

CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and …

GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active and potent inhibitor of type I protein …

AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).

AZ-3 is a potent and selective JAK1 inhibitor (IC50: 34 nM).

JDTic is a powerful antagonist of kappa-opioid receptors (KOR), effectively inhibiting the antinociceptive effects induced …

JAK-IN-5 hydrochloride is a JAK inhibitor [1].

GDC-0339 is discovered as a potential treatment of multiple myeloma. GDC-0339 is an orally bioavailable …

Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo. Mefuparib …

ITK inhibitor 2 is a interleukin-2-inducible T-cell kinase (ITK) inhibitor , with an IC50 of …

(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).

PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide is a potent and selective Enhancer of Zeste Homolog 2 (EZH2) inhibitor with IC50 …

EZH2-IN-2 is a EZH2 inhibitor with an IC50 of 64 nM.

CMP 10 (Dot1L-IN-4) is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor.