Sirtuin
Sirtuine sind eine Familie von NAD+-abhängigen Deacetylasen, die eine entscheidende Rolle bei der Regulierung zellulärer Prozesse wie DNA-Reparatur, Alterung, Stoffwechsel und Stressresistenz spielen. Sirtuine beeinflussen die DNA-Reparatur, indem sie Proteine in den Reparaturwegen deacetylieren und so deren Aktivität modulieren. Sirtuin-Inhibitoren und -Aktivatoren sind wertvolle Werkzeuge in der Forschung zu Alterung, Krebs und Stoffwechselkrankheiten, bei denen die Regulation der DNA-Reparatur und der zellulären Langlebigkeit von Interesse ist. Bei CymitQuimica bieten wir eine Reihe hochwertiger Sirtuin-Modulatoren zur Unterstützung Ihrer Forschung in den Bereichen DNA-Reparatur, Zellalterung und Stoffwechselregulation an.
86 Produkte aus dem Bereich "Sirtuin" gefunden
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Nicotinamide riboside
CAS:Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-
Formel:C11H15N2O5Reinheit:98.82% - 99.58%Farbe und Form:SolidMolekulargewicht:255.25Resveratrol
CAS:Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.Formel:C14H12O3Reinheit:99.82% - 99.96%Farbe und Form:Off-White To Tan PowderMolekulargewicht:228.24SIRT-IN-2
CAS:SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).Formel:C15H21N5O3S2Reinheit:98.26%Farbe und Form:SolidMolekulargewicht:383.49Ref: TM-T12919
1mg92,00€5mg215,00€10mg344,00€25mg587,00€50mg803,00€100mg1.099,00€200mg1.468,00€1mL*10mM (DMSO)236,00€MC3482
CAS:MC3482 is a specific inhibitor of sirtuin5 (SIRT5).Formel:C33H38N4O8Reinheit:98% - 99.90%Farbe und Form:SoildMolekulargewicht:618.68Ref: TM-T11962
1mg50,00€2mg71,00€5mg105,00€10mg170,00€25mg268,00€50mg423,00€100mg685,00€500mg1.378,00€SIRT5 inhibitor 8
CAS:SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.Formel:C22H25ClN8O2SReinheit:99.56%Farbe und Form:SolidMolekulargewicht:501SIRT1 activator 1
SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp.Reinheit:98%Farbe und Form:Odour SolidSIRT5 inhibitor 9
CAS:SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Formel:C24H29ClN8O4SReinheit:98.68%Farbe und Form:SolidMolekulargewicht:561.06Et-29
CAS:Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.Formel:C34H46N6O6SReinheit:99.52%Farbe und Form:SolidMolekulargewicht:666.83SIRT2-IN-17
SIRT2-IN-17 (compound Z18) is a potent inhibitor of SIRT2, effectively reducing the expression of α-SMA and p-Smad2/3.Formel:C24H15N3O2SFarbe und Form:SolidMolekulargewicht:409.46WAY-323061
CAS:WAY-323061 is a SIRT2 inhibitor.Formel:C25H21N5O2SReinheit:99.33%Farbe und Form:SolidMolekulargewicht:455.53SIRT1-IN-1
CAS:SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.Formel:C14H16N2OReinheit:99.58%Farbe und Form:SolidMolekulargewicht:228.29Ref: TM-T9648
1mg92,00€5mg192,00€10mg295,00€25mg505,00€50mg708,00€100mg964,00€200mg1.288,00€1mL*10mM (DMSO)195,00€SIRT2-IN-16
SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).Formel:C55H91N9O15SFarbe und Form:SolidMolekulargewicht:1150.43Z26395438
CAS:Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.Formel:C17H15FN2OReinheit:99.54%Farbe und Form:SolidMolekulargewicht:282.31Ref: TM-T77653
1mg34,00€2mg77,00€5mg77,00€10mg105,00€25mg187,00€50mg269,00€100mg398,00€500mg1.333,00€MIND4-19
CAS:MIND4-19 is an inhibitor of SIRT2 with antitumor activity.Formel:C22H19N3OSReinheit:99.9%Farbe und Form:SolidMolekulargewicht:373.47Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Formel:C19H15N3O2SReinheit:99.67%Farbe und Form:SolidMolekulargewicht:349.41SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Formel:C22H24N2O9SFarbe und Form:SolidMolekulargewicht:492.5SIRT-IN-5
SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.Farbe und Form:Odour SolidBenzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS:3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.Formel:C20H15N3O2SReinheit:99.32%Farbe und Form:SolidMolekulargewicht:361.42Sirt1/2-IN-4
Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (Formel:C21H20N4O3S2Reinheit:98%Farbe und Form:SolidMolekulargewicht:440.54SIRT5 inhibitor 3
CAS:SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .Formel:C22H12FN3O4Reinheit:98%Farbe und Form:SolidMolekulargewicht:401.35
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