Nrf2
Nrf2 ist ein Transkriptionsfaktor, der die Expression von antioxidativen Proteinen und Entgiftungsenzymen reguliert und eine entscheidende Rolle beim zellulären Schutz vor oxidativem Stress und Entzündungen spielt. Die Aktivierung der Nrf2-Signalwege bietet Schutz vor verschiedenen Krankheiten, einschließlich Krebs, Neurodegeneration und Herz-Kreislauf-Erkrankungen. Nrf2-Modulatoren werden auf ihr therapeutisches Potenzial zur Verringerung von oxidativem Schaden und Entzündungen untersucht. Bei CymitQuimica bieten wir eine Auswahl hochwertiger Nrf2-Wegmodulatoren zur Unterstützung Ihrer Forschung in den Bereichen oxidativer Stress, Entzündungen und Krankheitsprävention an.
78 Produkte aus dem Bereich "Nrf2" gefunden
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BPK-29 hydrochloride
CAS:<p>"BPK-29 hydrochloride targets NR0B1, altering C274 and hinders KEAP1-mutant cancer cell growth."</p>Formel:C26H33Cl2N3O3Reinheit:99.06%Farbe und Form:SolidMolekulargewicht:506.46Ezetimibe
CAS:<p>Ezetimibe (SCH 58235) is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.</p>Formel:C24H21F2NO3Reinheit:97.28% - 99.77%Farbe und Form:SolidMolekulargewicht:409.43NK-252
CAS:<p>NK-252 is a potential activator of Nrf2. It has great Nrf2-activating potential.</p>Formel:C13H11N5O3Reinheit:98.32%Farbe und Form:SolidMolekulargewicht:285.26AA147
CAS:<p>AA147 is an ER proteostasis regulator that selectively activates the ATF6 arm of UPR as a prodrug.</p>Formel:C16H17NO2Reinheit:99.24%Farbe und Form:SolidMolekulargewicht:255.31(E/Z)-BCI
CAS:<p>(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS</p>Formel:C22H23NOReinheit:99.94%Farbe und Form:SolidMolekulargewicht:317.42Deacetylgedunin
CAS:<p>Deacetylgedunin is a limonoid that is the 7-deacetyl derivative of gedunin. It has been isolated from Azadirachta indica.</p>Formel:C26H32O6Farbe und Form:SolidMolekulargewicht:440.53S217879
<p>S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway.</p>Formel:C29H30N4O7SFarbe und Form:SolidMolekulargewicht:578.64Keap1/Nrf2/ARE activator 1
<p>Keap1/Nrf2/ARE activator 1 (compound HT-3) functions as an activator of the Keap1/Nrf2/ARE pathway. This compound has antioxidant properties and offers neuroprotective effects.</p>Formel:C19H20O6Farbe und Form:SolidMolekulargewicht:344.12599Monascin
CAS:<p>Monascin: azaphilonoid in red-mold rice; anti-tumor and anti-inflammatory.</p>Formel:C21H26O5Reinheit:98%Farbe und Form:SolidMolekulargewicht:358.43Keap1-IN-1
<p>Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.</p>Formel:C17H21Cl2N2O5PS3Farbe und Form:SolidMolekulargewicht:531.434Nrf2 activator-8
<p>Nrf2 Activator-8 (Compound 10e), with an EC50 of 37.9 nM, is a potent Nrf2 activator that demonstrates significant antioxidant and anti-inflammatory properties</p>Formel:C13H11ClN2O3SFarbe und Form:SolidMolekulargewicht:310.7617-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
CAS:<p>Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.</p>Formel:C22H30O3Farbe und Form:SolidMolekulargewicht:342.479TPNA10168
CAS:<p>Compound Fr13590, with CAS No. 957942-34-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13590 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formel:C9H9ClO2S2Farbe und Form:SolidMolekulargewicht:248.75Keap1-Nrf2-IN-9
CAS:<p>Keap1-Nrf2-IN-9 inhibits Keap1-Nrf2 PPI with 0.575 µM IC50, boosts Nrf2 genes, non-toxic in ARPE19 cells.</p>Formel:C31H30N2O11S2Farbe und Form:SolidMolekulargewicht:670.71TAT 14
CAS:<p>TAT 14: a 14-mer peptide Nrf2 activator, anti-inflammatory, boosts Nrf2 protein, targets Keap1, no effect on mRNA.</p>Formel:C137H230N48O39Reinheit:98%Farbe und Form:SolidMolekulargewicht:3173.59Keap1-Nrf2-IN-27
<p>Keap1-Nrf2-IN-27 is an inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) with a KD2 value of 0.119 μM. It suppresses the expression of pro-inflammatory cytokines TNF-α and IL-6 in an LPS-induced RAW264.7 cell model.</p>Farbe und Form:Odour SolidButan-1-amine hydrochloride
CAS:<p>1-Butylamine hydrochloride,butylamine, a potential agonist of Nrf2/ARE (Nuclear Factor Erythroid 2 Associated Factor 2/Antioxidant Response Element).</p>Formel:C4H12ClNFarbe und Form:SolidMolekulargewicht:109.6Keap1-Nrf2-IN-3
CAS:<p>Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.</p>Formel:C31H34N6O3Farbe und Form:SolidMolekulargewicht:538.652Pterisolic acid B
<p>Pterisolic acid B is a useful organic compound for research related to life sciences and the catalog number is T125924.</p>Formel:C20H26O4Farbe und Form:SolidMolekulargewicht:330.424Nrf2/HO-1 activator 3
<p>Nrf2/HO-1 Activator 3 (Compound C3a) is an activator of the Nrf2 signaling pathway that facilitates the translocation of Nrf2 into the nucleus and enhances the expression of heme oxygenase-1 (HO-1). In H9c2 cardiomyocytes subjected to H2O2 or high glucose stimulation, Nrf2/HO-1 Activator 3 inhibits the excessive expression of ROS and MDA, suppressing cell viability and colony formation, thereby exhibiting antioxidant activity.</p>Formel:C27H26N2O6Farbe und Form:SolidMolekulargewicht:474.51
