MEK
MEK ist eine dual-spezifische Kinase, die eine zentrale Rolle im MAPK/ERK-Signalweg spielt, indem sie ERK durch Phosphorylierung aktiviert. Die MEK-Signalübertragung ist entscheidend für die Regulierung von Zellwachstum, Überleben und Differenzierung. Abnormale MEK-Aktivität wurde mit verschiedenen Krebsarten und Entwicklungsstörungen in Verbindung gebracht, was sie zu einem wichtigen therapeutischen Ziel macht. Bei CymitQuimica bieten wir eine Vielzahl von MEK-Inhibitoren und Modulatoren zur Unterstützung Ihrer Forschung in den Bereichen Onkologie, Zellsignalübertragung und therapeutische Entwicklung an.
74 Produkte aus dem Bereich "MEK" gefunden
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Lidocaine
CAS:Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.Formel:C14H22N2OReinheit:99.95% - >99.99%Farbe und Form:Needles From Benzene Or Alcohol SolidMolekulargewicht:234.34Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Formel:C14H22N2O·HCl·H2OReinheit:99.95%Farbe und Form:SolidMolekulargewicht:288.82Lidocaine hydrochloride
CAS:Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.Formel:C14H23ClN2OReinheit:99.81% - 99.92%Farbe und Form:White Crystal PowderMolekulargewicht:270.798DS03090629
DS03090629, an orally active MEK inhibitor, functions by competitively inhibiting MEK activity in the presence of ATP. This compound demonstrates strong binding affinity to both MEK and phosphorylated MEK, with dissociation constants (Kd) of 0.11 and 0.15 nM, respectively. It has shown efficacy in suppressing the proliferation of melanoma cell lines that overexpress BRAF mutations, achieving IC50 values of 74.3 and 97.8 nM for BRAF V600E and MEK1 F53L transfected A375 cells, respectively. DS03090629 is thus considered promising for anti-melanoma therapies.Formel:C25H26ClN5O2Farbe und Form:SolidMolekulargewicht:463.96MEK1/2-IN-3
MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.Formel:C28H23F3IN3O4Farbe und Form:SolidMolekulargewicht:649.4Cobimetinib (R-enantiomer)
CAS:Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.Formel:C21H21F3IN3O2Reinheit:98%Farbe und Form:SolidMolekulargewicht:531.318MEK4 inhibitor-1
CAS:MEK4 inhibitor-1 targets MEK4 enzyme in pancreatic cancer, IC50=61 nM.Formel:C13H10FN3O2SFarbe und Form:SolidMolekulargewicht:291.3PD 198306
CAS:PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Formel:C18H16F3IN2O2Reinheit:99.66%Farbe und Form:SolidMolekulargewicht:476.23Ref: TM-T21980
1mg64,00€5mg138,00€10mg188,00€25mg330,00€50mg472,00€100mg655,00€500mg1.293,00€1mL*10mM (DMSO)160,00€MEK/PI3K-IN-1
CAS:MEK/PI3K-IN-1 (6r) is a dual MEK/PI3K inhibitor; IC50: 124 nM (MEK1), 130 nM (PI3Kα), 236 nM (PI3Kδ). It reduces pAKT, pERK1/2, and hinders tumor growth.Formel:C36H37F5IN9O6Farbe und Form:SolidMolekulargewicht:913.63FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
Farbe und Form:LiquidMAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Farbe und Form:Odour SolidRef: TM-L1400
1mgNachfragen30μL*10mM (DMSO)Nachfragen50μL*10mM (DMSO)Nachfragen100μL*10mM (DMSO)Nachfragen250μL*10mM (DMSO)NachfragenDebromohymenialdisine
CAS:Debromohymenialdisine is a natural product for research related to life sciences. The catalog number is T35596 and the CAS number is 75593-17-8.Formel:C11H11N5O2Farbe und Form:SolidMolekulargewicht:245.242NST-628
CAS:NST-628 is a pan-RAF-MEK molecular glue that prevents RAF from phosphorylating and activating MEK. NST-628 inhibits the RAF-MEK signaling complex.Formel:C22H18F2N4O5SReinheit:98.62% - 98.86%Farbe und Form:SolidMolekulargewicht:488.46U0124
CAS:Inactive analog of U0126(MEK-1/2 inhibitor), used as a negative controlFormel:C8H10N4S2Reinheit:98%Farbe und Form:SolidMolekulargewicht:226.32MS432
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.Formel:C50H65F3IN7O6SReinheit:98%Farbe und Form:SolidMolekulargewicht:1076.06Midkine Protein, Human, Recombinant (His & Avi), Biotinylated
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asFarbe und Form:Lyophilized PowderMolekulargewicht:16.46 kDa (predicted) same as Tris-Bis PAGE result.Ref: TM-TMPK-00024
5µg91,00€10µg150,00€20µg239,00€50µg471,00€100µg779,00€200µg1.410,00€500µg3.018,00€Midkine Protein, Mouse, Recombinant (His)
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asReinheit:> 95% as determined by Bis-Tris PAGE - > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLCFarbe und Form:Lyophilized PowderMolekulargewicht:14.03 kDa (predicted). The protein migrates to 17-20 kDa based on Tris-Bis PAGE result.Midkine Protein, Human, Recombinant (His & Avi)
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asFarbe und Form:Lyophilized PowderMolekulargewicht:16.46 kDa (predicted) same as Tris-Bis PAGE result.Anti-Midkine Antibody (5T766)
Anti-Midkine Antibody (5T766) is an antibody targeting Midkine. Anti-Midkine Antibody (5T766) can be used in ELISA, IHC.Farbe und Form:Odour LiquidRGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formel:C29H35N7O4Reinheit:98% - 99.91%Farbe und Form:SolidMolekulargewicht:545.63
