Ras
Ras-Proteine sind kleine GTPasen, die als molekulare Schalter im MAPK-Signalweg wirken und das Zellwachstum, die Differenzierung und das Überleben kontrollieren. Aktiviertes Ras initiiert eine Signalkaskade, die Raf, MEK und ERK umfasst und zu verschiedenen zellulären Reaktionen führt. Mutationen in Ras-Genen sind in Krebsarten häufig, was Ras zu einem wichtigen Fokus der Krebsforschung macht. Bei CymitQuimica bieten wir eine Reihe von Ras-Modulatoren zur Unterstützung Ihrer Forschung in den Bereichen Krebsbiologie, Signaltransduktion und therapeutische Entwicklung an.
154 Produkte aus dem Bereich "Ras" gefunden
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Ketoconazole
CAS:Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.Formel:C26H28Cl2N4O4Reinheit:99.53% - 99.95%Farbe und Form:Crystals From 4-Methylpentanone SolidMolekulargewicht:531.43K-Ras G12C-IN-4
CAS:K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。Formel:C31H33ClN4O4Reinheit:99.00%Farbe und Form:SolidMolekulargewicht:561.07Ref: TM-T11738
1mg71,00€5mg161,00€10mg236,00€25mg403,00€50mg532,00€100mg783,00€200mg1.054,00€1mL*10mM (DMSO)192,00€ARS-1630
CAS:ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Formel:C21H17ClF2N4O2Reinheit:97.78%Farbe und Form:SolidMolekulargewicht:430.84Ref: TM-T10376
1mg38,00€5mg86,00€10mg112,00€25mg216,00€50mg310,00€100mg408,00€200mg580,00€1mL*10mM (DMSO)88,00€HJC0197
CAS:HJC0197 is a selective Epac antagonist; blocks cAMP-induced activation with IC50=5.9 μM for Epac2.Formel:C19H21N3OSReinheit:98.05%Farbe und Form:SolidMolekulargewicht:339.45Ref: TM-T15485
2mg38,00€5mg54,00€10mg86,00€25mg135,00€50mg188,00€100mg283,00€200mg426,00€1mL*10mM (DMSO)64,00€MRTX-1257
CAS:MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Formel:C33H39N7O2Reinheit:97.3% - 99.07%Farbe und Form:SolidMolekulargewicht:565.71Ref: TM-T16143
1mg60,00€2mg85,00€5mg124,00€10mg195,00€25mg351,00€50mg512,00€100mg743,00€200mg982,00€1mL*10mM (DMSO)166,00€BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Formel:C23H25F3N4O3Reinheit:99.2% - 99.66%Farbe und Form:SolidMolekulargewicht:462.46Ref: TM-T12979
1mg73,00€5mg160,00€10mg250,00€25mg464,00€50mg663,00€100mg919,00€500mg1.833,00€1mL*10mM (DMSO)170,00€MBQ-167
CAS:MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).Formel:C22H18N4Reinheit:98.07% - 99.52%Farbe und Form:SolidMolekulargewicht:338.41Ref: TM-T16021
1mg34,00€2mg49,00€5mg74,00€10mg105,00€25mg197,00€50mg356,00€100mg537,00€1mL*10mM (DMSO)82,00€G12 TFA
G12 (Ras5-17) TFA is a wild-type Ras peptide comprising amino acids 5-17 (KLVVVGAGGVGKS). It serves as a control in studies involving mutant Ras peptides, such as V12.Formel:C54H96F3N15O17Molekulargewicht:1283.70607KRASG12C IN-14
KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.Formel:C51H65F4N9O9S2Farbe und Form:SolidMolekulargewicht:1088.24KRAS G12D inhibitor 20
KRAS G12D inhibitor 20 (Compound 14) is a selective G12D KRAS inhibitor with antitumor activity.Formel:C18H26N6OMolekulargewicht:342.21681Rac1 Inhibitor W56
CAS:Peptide (45-60) blocks Rac1 binding with TrioN, GEF-H1, Tiam1 GEFs.Formel:C74H117N19O23SReinheit:98%Farbe und Form:SolidMolekulargewicht:1671.93KRAS inhibitor-42
KRAS inhibitor-42 (compound 8) is an effective USP7 inhibitor that exhibits high affinity for GDP-bound KRASG12D, with a Ki value of 2.7 μM.Formel:C34H47ClN8O4S2Farbe und Form:SolidMolekulargewicht:730.28502KRpep-2d
CAS:KRpep-2d, a potent inhibitor of K-Ras, effectively suppresses the proliferation of cancer cells driven by K-Ras.Formel:C109H183N43O25S2Farbe und Form:SolidMolekulargewicht:2560.02pan-KRAS-IN-10
Pan-KRAS-IN-10 (Compound 58) acts as an inhibitor of the human tumor mutant gene KRAS. It suppresses the proliferation of KRAS mutant cells, specifically AsPC-1 (G12D mutant) and SW480 (G12V mutant), with IC50 values of 0.7 and 0.24 nM, respectively.Formel:C45H57N7O5SMolekulargewicht:807.41419MC 976
CAS:MC 976 is a derivative of Vitamin D3.Formel:C27H42O3Reinheit:98%Farbe und Form:SolidMolekulargewicht:414.63MRTF-A-IN-2
MRTF-A-IN-2 (compound 16) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.Farbe und Form:Odour SolidADT-007
CAS:ADT-007 is a pan-RAS inhibitor with potent anticancer activity.Formel:C26H24FNO5Reinheit:97.75%Farbe und Form:SoildMolekulargewicht:449.47Ref: TM-T85316
1mg47,00€5mg96,00€10mg124,00€25mg200,00€50mg353,00€100mg602,00€200mg982,00€1mL*10mM (DMSO)104,00€MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Farbe und Form:Odour SolidRef: TM-L1400
1mgNachfragen30μL*10mM (DMSO)Nachfragen50μL*10mM (DMSO)Nachfragen100μL*10mM (DMSO)Nachfragen250μL*10mM (DMSO)Nachfragen6-Thio-GTP tetrasodium
6-Thio-GTP (tetrasodium) is an inhibitor of Vav1-Rac. It can suppress TCR-induced T cell proliferation and CD28-mediated T cell survival. In a murine model of allogeneic heart transplantation, 6-Thio-GTP (tetrasodium) demonstrates immunosuppressive effects, which can prolong the survival time of heart transplants.Formel:C10H12N5Na4O13P3SFarbe und Form:SolidMolekulargewicht:626.89559SEPT9-IN-1
SEPT9-IN-1 (compound 8b) is a SEPT9 inhibitor with an IC50 value of 94.83 μM. It exhibits cytotoxicity against human oral squamous carcinoma cells, with an IC50 of 21 µM.Formel:C26H30ClN3O3Farbe und Form:SolidMolekulargewicht:467.988
