Transporter/Ionenkanal

Rapastinel (TPPT-amide) (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator.

Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM …

Bamaquimast (L 0042) is a proton pump inhibitor for the study of asthma-like immune system …

Pandinotoxin Kα, a chemical compound extracted from the emperor scorpion (Pandinus imperator) venom, functions as …

KT-362 fumarate is a novel compound that acts as an antagonist of calcium channels, potassium …

Bulleyaconitine A (Bulleyaconi cine A), an analgesic and antiinflammatory drug isolated from Aconitum plants, has …

Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for …

κM-Conotoxin RIIIJ (κM-RIIIJ) selectively inhibits Kv1.2 channels, exhibiting an IC50 value of 33 nM [1].

Cirsimaritin exhibits antibacterial, anti-inflammation, anti-tumor, antioxidant properties and renal protection. Cirsimaritin binds weakly to the …

ω-Conotoxin Bu8 is a 25-amino-acid-residue ω-conotoxin that features three disulfide bridges. It selectively and potently …

Hongotoxin-1, a chemical compound isolated from the venom of Centruroides limbatus, functions as a potassium …

Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and …

LY836 is an orally active, neuroprotective compound that effectively inhibits the PSD95-nNOS association in cortical …

CRM1-IN-1 (Compound KL1), a noncovalent inhibitor of CRM1, promotes nuclear degradation of CRM1 with an …

VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 …

JTV-519 fumarate (K201 fumarate) is a SERCA blocker and partial agonist at the ryanodine receptor …

Heteropodatoxin-1 (HpTx1), a spider peptide toxin, acts as an inhibitor of the Kv4.2 current, while …

PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].

A 839977 is a selective P2X7 receptor antagonist with anti-inflammatory and analgesic activity that inhibits …

Nav1.8-IN-4 is a potent Nav1.8 channel inhibitor with potential analgesic activity.Nav1.8-IN-4 can be used for …

MitTx, a complex consisting of MitTx-α and MitTx-β, serves as an ASIC1 channel activator, demonstrating …

3'-Methoxydaidzein is a dual isoflavone and Sodium Channel inhibitor. 3'-Methoxydaidzein inhibited NaV1.7, NaV1.8 and NaV1.3 …

Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium …

Gavestinel (GV 150526) is a non-competitive NMDA receptor antagonist that is potent, selective and orally …

Tamolarizine (Tamolarizine free base) free base is a novel calcium antagonist.

Clopimozide (R-29764) acts as a calcium channel antagonist and inhibits [3H] nilandipine binding.Clopimozide is a …

Amlodipine maleate (Amvaz) is an orally active dihydropyridine calcium channel blocker that inhibits calcium inward …

ProTx-III, a spider venom peptide derived from the Peruvian green velvet tarantula, functions as a …

Cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV …

1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an …

TASK-1-IN-1 is a potent and selective inhibitor of TASK-1 (Potassium Channel) (IC50: 148 nM).TASK-1-IN-1 has …

Nerisopam is an agonist of gamma-aminobutyric acid (GABA) receptor.

Fengabine (SL-79229) is a GABA receptor agonist with antidepressant activity and is used to treat …

6-Hydroxyflavanone, extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by …

FS-2 is a potent, specific inhibitor of L-type CaV channels, effectively impeding high K+ or …

Tuvatexib is a small molecule VDAC/HK2 dual modulator.

Vesnarinone HCl (OPC-8212 HCl) is an orally active phosphodiesterase 3 (PDE3) inhibitor.Vesnarinone HCl modulates calcium …

Pazinaclone is a non-benzodiazepine (GABAA) partial agonist with sedative and anxiolytic activity.

Pafenolol is a P-glycoprotein modulator with a Ki value of 5.5 µM. pafenolol is an …

Oxodipine, a dihydropyridine-type calcium antagonist , inhibited KCl-induced aortic contraction in rabbits and reduced cardiac …

Bupivacaine hydrochloride monohydrate is a potent NMDA receptor inhibitor of sodium, L-calcium, and potassium channels.Bupivacaine …

µ-Conotoxin-CnIIIC acetate is a potent NaV1.4 sodium channel antagonist, a conotoxin peptide consisting of 22 …

Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity, and its effects are related to cardiac activity and …

2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-(phenylsulfonyl)- is a potent KCNQ1 channel activator that can be used in long QT …

TTA-A8 is an antagonist of T-type calcium channel.

Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a metabolite of nicotinamide adenine nucleotide (NAD+), which …

Transcainide(R 54718), a new lidocaine analog, is an orally active antiarrhythmic agent.Transcainide blocks the open …

RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 …

Suzetrigine(VX-548) is an orally active and specific NaV1.8 inhibitor. Suzetrigine has analgesic activity and can …

Imperatoxin A, a peptide toxin sourced from the African scorpion Pandinus imperator, functions as an …

KV1.3-IN-1 (Compound trans-18), a selective KV1.3 channel inhibitor with IC50 values of 230 nM in …

Anthopleurin-C (APE 2-1) is a cardiotonic polypeptide exhibiting a potent positive inotropic effect [1].

γ-Glutamylserine TFA (γ-Glu-Ser TFA) serves as a calcium receptor activator and is utilized in research …

Jingzhaotoxin-X (JZTX-X) selectively inhibits Kv4.2 and Kv4.3 potassium channels, resulting in prolonged mechanical hyperalgesia [1].

Myr-TAT-CBD3, a CRMP2-CaV2.2 interaction inhibitor, has been shown to significantly attenuate carrageenan-induced thermal hypersensitivity and …

Pe1b (μ-TrTx-Pe1b) is a selective inhibitor of the NaV1.7 channel, exhibiting an inhibitory concentration 50 …

Jingzhaotoxin-IX is a C-terminally amidated peptide neurotoxin consisting of 35 amino acid residues. It inhibits …

GABA receptor Antagonist 1 (compound 7w) effectively inhibits the Px RDL1 GABAR at an IC50 …

Nav1.3 Channel Inhibitor 1 (Compound 15b) is a state-dependent inhibitor of the voltage-gated sodium channel …

Lactate Transporter 1 (Compound 1) serves as an active lactate transporter within living cells and …

Micrurotoxin 1 (MmTx1 toxin) acts as an allosteric modulator of GABA A receptors, enhancing the …

Tamapin, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets …