Transporter/Ionenkanal

Kurtoxin is a selective Cav3 (T-type) voltage-gated Ca2+ channel gating inhibitor, exhibiting a dissociation constant …

δ-Theraphotoxin-Hm1a is a selective NaV1.1 activator that induces pain and touch sensitivity, with potential applications …

Cav 3.2 Inhibitor 4 (Compound 21) is a selective and potent inhibitor of the T-type …

Dc1a, a toxin isolated from the desert bush spider Diguetia canities [1], potently facilitates the …

ProTx-II TFA is a potent and highly selective Nav1.7 sodium channel blocker, exhibiting an IC50 …

Hm1a, a disulfide-rich spider-venom peptide and NaV1.1 activator, reestablishes the function of inhibitory interneurons in …

ShK toxin, isolated from the Caribbean sea anemone (Stichodactyla helianthus), is an inhibitor of the …

Jingzhaotoxin-V, a 29-residue polypeptide from Chilobrachys jingzhao spider venom, selectively inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium …

ω-Conotoxin CVIE selectively inhibits voltage-gated Ca^2+ channels (Ca_v 2.2) [1].

S-Pantoprazole (sodium trihydrate), a variant of Pantoprazole, is pivotal in managing diseases associated with gastric …

Margatoxin TFA, an alpha-KTx scorpion toxin isolated from Centruroides margaritatus venom, is a 39-amino-acid peptide …

Scorpion toxin Tf2, a β-scorpion toxin first identified in the venom of the Brazilian scorpion …

Noxiustoxin, a toxin extracted from the venom of the Mexican scorpion Centruroides noxius, inhibits both …

Slotoxin, a peptide extracted from the venom of the Centruroides noxius Hoffmann scorpion, inhibits high-conductance …

HsTX1, a 34-residue, C-terminally amidated peptide isolated from the scorpion Heterometrus spinnifer, features four disulfide …

Huwentoxin I (HWTX-I) is a peptide toxin that targets and inhibits both voltage-gated sodium channels …

Tamapin TFA, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively …

AMPA receptor modulator-6, an AMPA receptor positive allosteric modulator (PAM), is utilized in the research …

Aneratrigine is a blocker of the sodium channel protein type 9 subunit alpha, utilized in …

Myoregulin (MLN peptide) TFA, belonging to the regulin family, is a regulator of muscle performance …

Compound (R)-10a, an NMDA receptor antagonist, exhibits selectivity for the GluN2B subunit, possessing a Ki …

(R)-Elexacaftor, an enantiomer of Elexacaftor, functions as a modulator of the cystic fibrosis transmembrane conductance …

Phrixotoxin 2 selectively blocks the KV 4.2 and KV 4.3 channels, demonstrating high specificity in …

Verdinexor (KPT-335) (KPT-335), a specific XPO1/CRM1 inhibitor, are orally bioavailable.

TMDJ-035 is a selective inhibitor of the RyR2 (ryanodine receptor 2). It effectively suppresses abnormal …

DQP-26, a potent negative allosteric modulator of NMDA receptors (NMDARs), exhibits IC50 values of 0.77 …

ent-8(14),15-pimaradien-3beta-ol (8(14),15-Isopimaradien-3-ol) can induce vascular relaxation. It displays high antibacterial activities (MIC values lower than …

δ-Buthitoxin-Hj2a, a potent scorpion-venom peptide, acts as a NaV1.1 agonist with an EC50 value of …

Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.

ANO1-IN-1, a selective ANO1 channel blocker, inhibited ANO1 and ANO2 with IC50 values of 2.56 …

Oxidized ATP trisodium salt (oATP) is a broad-spectrum inhibitor of P2 receptors, irreversibly antagonizing P2X7R …

Thevetin B is a cardiac glycoside and an inhibitor of Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) from …

Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked …

Hainantoxin-IV acts as a specific antagonist for tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with His28 and …

μ-Conotoxin PIIIA, isolated from Conus purpurascens [1] [2], is a blocker of the sodium channel …

GrTx1, a peptide toxin derived from Grammostola rosea spider venom, selectively inhibits sodium channels Nav1.1, …

Maurotoxin, a 34-residue peptide featuring four disulfide bridges, is extracted from the chactoid scorpion (Scorpio …

2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-feeding insect, the cotton …

Rislenemdaz (CERC-301) (CERC-301) is an antagonist of the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B).

Jingzhaotoxin-34, a 35-residue neurotoxic polypeptide, selectively inhibits tetrodotoxin-sensitive (TTX-S) sodium currents in rat dorsal root …

Maurocalcine is a cell-permeable agonist for ryanodine receptor (RyR) subtypes 1, 2, and 3. It …

DS16570511 is a novel, cell-permeable inhibitor targeting the mitochondrial calcium uniporter. It effectively blocks the …

FEMA-4809, a highly potent TRPM8 receptor activator, TRPM8 is the ion channel responsible for the …

μ-Conotoxin BuIIIA (Mu-Conotoxin BuIIIA), a toxin derived from Cone snail venom, functions as a voltage-gated …

μ-Conotoxin-CnIIIC, a 22-residue conopeptide derived from Conus consors, acts as a potent and persistent NaV1.4 …

ML353 (VU0478006) is a selective activator of TREK-1 and TREK-2 and a selective ligand (Ki …

μ-TRTX-Hd1a, a spider venom-derived compound, selectively inhibits the human NaV 1.7 channel by functioning as …

NecroX-5, a derivative of NecroX, exhibits anti-inflammatory and anti-cancer activities. NecroX-5 reduces intracellular calcium concentration.

GpTx-1 exhibits potent selectivity as a NaV1.7 antagonist, demonstrating an inhibition concentration (IC50) of 10 …

Ticolubant is orally active leukotriene B4 antagonist with high affinity for the human neutrophil LTB4 …

Guvacine hydrobromide, an alkaloid derived from the Areca catechu nut, serves as a potent inhibitor …

Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the …

Bryonolic acid (20-epi-Bryonolic acid), a triterpenoid extracted from Sandoricum indicum, possesses immunomodulatory, anti-inflammatory, antioxidant and …

ω-Hexatoxin-Hv1a, a neurotoxin extracted from the venom of the spider Hadronyche versuta, inhibits voltage-gated calcium …

π-TRTX-Hm3a, a 37-amino acid peptide derived from the venom of the Togo starburst tarantula (Heteroscodra …

Muscimol HBr (Agarin HBr) is an agonist of GABAA receptor.

Epaminurad HCl is a URAT1 inhibitor with partial inhibition of OAT1 and OAT3 (organic anion …

Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and …

Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS …

Phaclofen (3-Amino-2-(4-chlorophenyl)propanephosphonic acid) is a selective GABAB receptor antagonist, which can partially antagonize the sedative …

δ-Dendrotoxin is a potassium (K+) channel blocker derived from black mamba snake venom and is …

Gallopamil hydrochloride (Methoxyverapamil hydrochloride) is an antagonist of phenylalkylamine calcium. Gallopamil hydrochloride can be used …

Encecalin and demethylencecalin are major phytotoxic compounds isolated from Helianthella quinquenervis (Hook) A Gray (Asteraceae), …

ATX-II TFA, a specific Na+ channel modulator toxin, is derived from the venom of the …

mHuwentoxin-IV, a naturally modified form of Huwentoxin-IV, selectively inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels in …

PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also …

Zandatrigine (NBI-921352) is a blocker of sodium channel protein type 8 subunit alpha and can …

Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid …