FXR
Der Farnesoid-X-Rezeptor (FXR) ist ein nuklearer Rezeptor, der eine Schlüsselrolle bei der Regulierung der Gallensäurehomöostase, des Lipidstoffwechsels und der Glukoseregulation spielt. FXR ist ein potenzielles therapeutisches Ziel zur Behandlung von Lebererkrankungen, Stoffwechselstörungen und Herz-Kreislauf-Erkrankungen. FXR-Inhibitoren können diese Signalwege modulieren und bieten Einblicke in Krankheitsmechanismen und therapeutische Strategien. Bei CymitQuimica bieten wir eine Reihe von FXR-Inhibitoren an, um Ihre Forschung in den Bereichen Hepatologie, Stoffwechsel und Wirkstoffentwicklung zu unterstützen.
58 Produkte aus dem Bereich "FXR" gefunden
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LY2562175
CAS:<p>LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).</p>Formel:C28H27Cl2N3O4Reinheit:99.16% - 99.78%Farbe und Form:SolidMolekulargewicht:540.44Ursodeoxycholic acid
CAS:<p>Ursodeoxycholic acid (UDCA) is a potent inhibitor of liver-specific fatty acid transporter 5 (FATP5),inhibits cholesterol absorption. High-Quality, Low-Cost!</p>Formel:C24H40O4Reinheit:99.74% - ≥95%Farbe und Form:White - Almost White Solid PowderMolekulargewicht:392.57Chenodeoxycholic acid
CAS:<p>Chenodeoxycholic acid (CDCA) is a bile acid that inhibits 11β-HSD2 with an IC50 value of 22 mM. High-Quality, Low-Cost!</p>Formel:C24H40O4Reinheit:99.70% - 99.93%Farbe und Form:White - Almost White Solid PowderMolekulargewicht:392.57ZLY28
<p>ZLY28 is a novel, first-in-class compound with specific intestinal restriction and oral activity, serving as a dual modulator of FXR and FABP1.</p>Formel:C29H23Cl2NO4Reinheit:98%Farbe und Form:SolidMolekulargewicht:520.4Alismanol M
CAS:<p>Alismanol M: FXR agonist, EC50 of 50.25 μM, from Alisma orientale, for cholestasis & NASH research.</p>Formel:C30H48O6Farbe und Form:SolidMolekulargewicht:504.7FXR antagonist 2
CAS:<p>Compound A-26, a diarylamide FXR blocker, may aid hyperlipidemia and diabetes type 2 research.</p>Formel:C22H26Cl2N2O2Farbe und Form:SolidMolekulargewicht:421.36LZ-007
CAS:<p>LZ-007 is an agonist of the Farnesoid X receptor (FXR), with an EC50 of 51 nM as determined by TR-FRET assay, and an EC50 of 76 nM in HepG2 cells. It exhibits favorable pharmacokinetic properties in SD rats and can improve metabolic dysfunction-associated steatohepatitis induced by high-fat diets and CCl4 in mice.</p>Formel:C27H29F3N2O5Farbe und Form:SolidMolekulargewicht:518.53FXR agonist 11
CAS:<p>FXR agonist11 (Compound 14) is an FXR activator with an EC50 of 1.2 μM and a maximal effect of 73.7%. It significantly increases GSH levels in the liver and is used to study drug-induced liver injury.</p>Formel:C18H16N2O5Farbe und Form:SolidMolekulargewicht:340.33Fexarene
CAS:<p>Fexarene is a non-steroidal FXR agonist.</p>Formel:C32H33NO3Reinheit:98%Farbe und Form:SolidMolekulargewicht:479.62LH10
<p>LH10 is an FXR agonist based on fexaramine, with an EC50 of 0.14 μM. It offers hepatoprotective effects, mitigating conditions such as cholestasis induced by alpha naphthylisothiocyanate (ANIT), acute liver injury caused by APAP, and non-alcoholic steatohepatitis (NASH).</p>Formel:C34H33N3O2Farbe und Form:SolidMolekulargewicht:515.64FXR agonist 10
<p>FXR agonist10 (Compound 27) acts as an agonist for FXR with an EC50 of 14.26 μM. It increases the expression of SHP and BSEP proteins while decreasing the expression of NTCP and CYP7A1 proteins. Additionally, FXR agonist10 has been shown to ameliorate ANIT-induced cholestasis in mouse models.</p>Formel:C15H22O4Farbe und Form:SolidMolekulargewicht:266.33FXR/TGR5 agonist 1
CAS:<p>FXR/TGR5 agonist 1 acts as an agonist on both FXR and TGR5 receptors and is utilized for treating fatty liver disease.</p>Formel:C31H32ClN3O3Farbe und Form:SolidMolekulargewicht:530.07FXR agonist 5
CAS:<p>FXR agonist 5 is an FXR agonist used in the study of liver diseases or diseases mediated by metabolic inflammation.</p>Formel:C40H53N5O5Reinheit:99.74%Farbe und Form:SolidMolekulargewicht:683.88Tauro-β-muricholic acid sodium
CAS:<p>Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).</p>Formel:C26H44NNaO7SReinheit:98%Farbe und Form:SolidMolekulargewicht:537.69Nuclear Receptor Compound Library
<p>A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;</p>Farbe und Form:Odour SolidNR1H4 Protein, Mouse, Recombinant (His)
<p>NR1H4 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27.80 kDa.</p>Farbe und Form:Lyophilized PowderMolekulargewicht:27.80 kDa (predicted)NR1H4 Protein, Human, Recombinant (His)
<p>NR1H4 Protein, Human, Recombinant (His) is expressed in E.</p>Farbe und Form:Lyophilized PowderMolekulargewicht:27.83 kDa (predicted)NDB
CAS:<p>NDB is a hFXRα antagonist that inhibits GW4064-stimulated FXR/RXR interactions in primary mouse hepatocytes.NDB is used in the study of diabetes.</p>Formel:C26H28Cl2N2O2Reinheit:98.94%Farbe und Form:SolidMolekulargewicht:471.42FXR agonist 3
<p>FXR agonist 3 is an anti NASH compound with anti-fibrotic and active properties that inhibits the expression of COL1A1, TGF-β1, α-SMA and TIMP1.</p>Formel:C28H28BrNO4Reinheit:95.04%Farbe und Form:SolidMolekulargewicht:521.12Sevelamer hydrochloride
CAS:<p>Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption</p>Formel:(C3H7N·C3H5ClO·HCl)xReinheit:98%Farbe und Form:SolidMolekulargewicht:186.08
