Proteasom
Proteasom-Inhibitoren sind Verbindungen, die das Proteasom hemmen, einen großen Proteinkomplex, der für den Abbau unerwünschter oder beschädigter Proteine in der Zelle verantwortlich ist. Die Hemmung des Proteasoms führt zur Ansammlung von Proteinen, was zu einem Zellzyklusarrest und Apoptose führen kann, insbesondere in schnell teilenden Zellen wie Krebszellen. Proteasom-Inhibitoren sind in der Krebsforschung und -therapie, insbesondere bei der Behandlung von multiplem Myelom und anderen hämatologischen Malignomen, von entscheidender Bedeutung. Bei CymitQuimica bieten wir Proteasom-Inhibitoren an, um Ihre Forschung in den Bereichen Onkologie, Zellbiologie und Arzneimittelentwicklung zu unterstützen.
89 Produkte aus dem Bereich "Proteasom" gefunden
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Trelagliptin
CAS:Trelagliptin (SYR-472) is a highly specific and long-acting DPP-4 inhibitor.Formel:C18H20FN5O2Reinheit:98.88%Farbe und Form:SolidMolekulargewicht:357.38UT-34
CAS:UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wildFormel:C15H12F4N4O2Reinheit:98.12%Farbe und Form:SolidMolekulargewicht:356.27Ref: TM-T13273
1mg50,00€5mg113,00€10mg177,00€25mg334,00€50mg505,00€100mg782,00€1mL*10mM (DMSO)124,00€RA190
CAS:RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.Formel:C28H23Cl5N2O2Reinheit:97.7%Farbe und Form:SolidMolekulargewicht:596.76Ref: TM-T13858
1mg54,00€5mg109,00€10mg159,00€25mg233,00€50mg414,00€100mg608,00€1mL*10mM (DMSO)142,00€Gly-Pro-pNA hydrochloride
CAS:Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride) is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidaseFormel:C13H17ClN4O4Reinheit:99.84%Farbe und Form:SolidMolekulargewicht:328.75Arimoclomol maleate
CAS:Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Formel:C18H24ClN3O7Reinheit:99.44% - 99.98%Farbe und Form:SolidMolekulargewicht:429.85Pepstatin
CAS:Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.Formel:C34H63N5O9Reinheit:96.74% - 99.94%Farbe und Form:SolidMolekulargewicht:685.89ML604440
CAS:ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.Formel:C17H24BF3N2O4Reinheit:97.06%Farbe und Form:SolidMolekulargewicht:388.19Ref: TM-T12079
1mg109,00€2mg158,00€5mg259,00€10mg409,00€25mg677,00€50mg954,00€100mg1.288,00€200mg1.728,00€1mL*10mM (DMSO)285,00€Gabexate mesylate
CAS:Gabexate mesylate (FOY) inhibits thrombin, plasmin, kallikrein; used for pancreatitis, DIC, hemodialysis anticoagulant.Formel:C17H27N3O7SReinheit:99.2% - 99.64%Farbe und Form:White CrystalMolekulargewicht:417.48RAMB4
CAS:RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.Formel:C19H13Cl4NOReinheit:98.89% - 99.38%Farbe und Form:SolidMolekulargewicht:413.12LMP7/LMP2-IN-1
CAS:LMP7/LMP2-IN-1 (Compound 19) is an orally effective inhibitor targeting the immunoproteasome subunits LMP7 and LMP2, with respective IC50 values of 257 and 10 nM. This compound reduces the production of antibodies and downregulates the B cells in the germinal centers of the spleen and plasma cells in NP-OVA immunized mice. It has potential applications in the study of autoimmune diseases.Formel:C16H27BN4O3Farbe und Form:SoildMolekulargewicht:334.22Dazcapistat
CAS:Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Formel:C21H18FN3O4Reinheit:99.11%Farbe und Form:SolidMolekulargewicht:395.38Ref: TM-T9710
1mg92,00€5mg192,00€10mg289,00€25mg522,00€50mg732,00€100mg1.018,00€1mL*10mM (DMSO)212,00€Acetyl-Calpastatin(184-210)(human), Negative Control
Acetyl-Calpastatin(184-210)(human), Negative Control is a control scrambled peptide corresponding to Acetyl-Calpastatin(184-210)(human). Acetyl-Calpastatin(184-210)(human) functions as a potent, selective, and reversible calpain inhibitor.Formel:C142H230N36O44SMolekulargewicht:3175.65874DPP8/9-IN-1
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.Farbe und Form:Odour SolidAcetyl-Calpastatin(184-210)(human) TFA
Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.Formel:C144H231F3N36O46SFarbe und Form:SolidMolekulargewicht:3291.65Acetyl-Calpastatin(184-210)(human)
CAS:Calpain inhibitor, Ki 0.2 nM for calpain I/II, doesn't affect papain/trypsin/cat L. Raises Aβ42, Aβ40 secretion & Aβ42/Aβ40 ratio.Formel:C142H230N36O44SReinheit:98%Farbe und Form:SolidMolekulargewicht:3177.65DPP-4-IN-14
DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.Formel:C33H27N7O3Farbe und Form:SolidMolekulargewicht:569.613VAMP
VAMP is a tetrapeptide that acts as a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor, exhibiting an IC50 of 1.00 μM and a Kd of 6.89 μM. It effectively targets the DPP-IV-GLP-1 axis and is utilized in the research of type 2 diabetes.Formel:C18H32N4O5SFarbe und Form:SolidMolekulargewicht:416.535LXE408 fumarate
LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.
Formel:C27H22FN7O6Reinheit:99.89%Farbe und Form:SoildMolekulargewicht:559.51Proteasome-IN-7
Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.Formel:C48H56N6O10SFarbe und Form:SolidMolekulargewicht:909.06Bortezomib analog
Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.Farbe und Form:Odour Solid
