c-Fms
c-Fms-Inhibitoren richten sich gegen den Colony-Stimulating-Factor-1-Rezeptor (c-Fms), eine Tyrosinkinase, die an der Regulation von Makrophagen und anderen Immunzellen beteiligt ist. Die c-Fms-Signalgebung spielt eine Rolle bei der Proliferation, Differenzierung und dem Überleben dieser Zellen. Eine Fehlregulation von c-Fms wird mit Krankheiten wie Krebs, entzündlichen Erkrankungen und Osteoporose in Verbindung gebracht. Bei CymitQuimica bieten wir c-Fms-Inhibitoren an, um Ihre Forschung in den Bereichen Immunologie, Onkologie und entzündliche Erkrankungen zu unterstützen.
105 Produkte aus dem Bereich "c-Fms" gefunden
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Mavrilimumab
CAS:Mavrilimumab (CAM 3001), a monoclonal antibody, blocks GM-CSF signaling, potentially reducing inflammation in rheumatoid arthritis.
Reinheit:> 95% - > 95%Farbe und Form:LiquidMolekulargewicht:143.2 kDaLacnotuzumab
CAS:Lacnotuzumab (MCS110) is a humanized monoclonal antibody targeting CSF-1, which can be used in research on retinal diseases.Reinheit:>95%Farbe und Form:LiquidMolekulargewicht:144.8 kDaCSF1R-IN-2
CAS:CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).Formel:C20H20FN7O2Reinheit:99.29%Farbe und Form:SolidMolekulargewicht:409.42CSF1R-IN-1
CAS:CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM.Formel:C25H20F3N5O2Reinheit:97.02% - 98.56%Farbe und Form:SolidMolekulargewicht:479.45Ref: TM-T10894
1mg88,00€5mg200,00€10mg309,00€25mg522,00€50mg747,00€100mg1.035,00€200mg1.378,00€1mL*10mM (DMSO)219,00€Emactuzumab
CAS:Emactuzumab(RG 7155) is a monoclonal antibody against colony-stimulating factor-1 receptor targeting tumor-associated macrophages (TAMs) Emactuzumab has
Reinheit:SDS-PAGE:98.3%;SEC-HPLC:97.3%Farbe und Form:LiquidMolekulargewicht:144.4 kDaEdicotinib
CAS:Edicotinib (JNJ-527) is a blood-brain permeable, selective CSF-1R inhibitor, with lesser inhibitory effects on KIT and FLT3.Cost-effective and quality-assured.
Formel:C27H35N5O2Reinheit:98.58% - 99.72%Farbe und Form:SolidMolekulargewicht:461.6M4205
CAS:M4205 is an inhibitor of c-Kit exhibiting high activity on c-Kit mutations in exons 11, 13, 17.Formel:C29H32N8OReinheit:99.07%Farbe und Form:SolidMolekulargewicht:508.62Ref: TM-T9689
1mg50,00€5mg110,00€10mg170,00€25mg290,00€50mg414,00€100mg572,00€200mg772,00€1mL*10mM (DMSO)122,00€Adrixetinib TFA
Adrixetinib (TFA) is a protein tyrosine kinase inhibitor that possesses antineoplastic properties [1] [2] [3].Farbe und Form:Odour SolidPyrithyldione
CAS:Pyrithyldione is a sedative-hypnotic agent known to potentially induce agranulocytosis.Formel:C9H13NO2Farbe und Form:SolidMolekulargewicht:167.21Antifibrotic agent 1
Antifibrotic agent 1 is an orally active medication designed to treat idiopathic pulmonary fibrosis (IPF). It effectively mitigates IPF-related processes, including TGF-β-induced epithelial-mesenchymal transition (EMT) and fibroblast-to-myofibroblast transition (FMT), as well as profibrotic M2 polarization. Antifibrotic agent 1 selectively inhibits CSF-1R, PDGFR-α, and Src family kinases (SFKs), while sparing VEGFR, FGFR, and Abl to minimize off-target toxicity. In a bleomycin (BLM)-induced pulmonary fibrosis mouse model, it demonstrates strong antifibrotic activity.Formel:C27H23ClN6O2Farbe und Form:SolidMolekulargewicht:498.1571PXB17
PXB17 inhibits CSF1R activation (IC50= 1.7 nM) by blocking the PI3K/AKT/mTORC1 signaling pathway. It is effective orally, significantly suppresses the growth of colorectal cancer (CRC), enhances the efficacy of PD-1 monoclonal antibodies (PD-1mAb), and reduces the recurrence of CRC tumors.Formel:C29H35N7O4Molekulargewicht:545.27505GENZ-882706(Raceme)
CAS:GENZ-882706(Raceme) is the racemate of GENZ-882706.Formel:C26H25N5O3Reinheit:98%Farbe und Form:SolidMolekulargewicht:455.51Eflapegrastim
CAS:Eflapegrastim: humanized IgG4 antibody and G-CSF that boosts neutrophils and shortens neutropenia.Farbe und Form:LiquidcFMS Receptor Inhibitor IV
CAS:cFMS Receptor Inhibitor IV is an inhibitor of c-Fms tyrosine kinase.
Formel:C22H26N4O2Reinheit:99.70%Farbe und Form:SolidMolekulargewicht:378.47Sotuletinib hydrochloride
CAS:Sotuletinib hydrochloride (BLZ945 HCl) is a selective, brain-penetrant CSF-1R (c-Fms) inhibitor (IC50=1 nM),for ALS and TNBC.Formel:C20H23ClN4O3SReinheit:98.812%Farbe und Form:SolidMolekulargewicht:434.94Gimsilumab
CAS:Gimsilumab (MORAb-022) is an anti-c-Fms humanized monoclonal antibody for the study of inflammation and hypoxemia caused by COVID-19.Reinheit:99.49% (SEC-HPLC) - 99.49% (SEC-HPLC)Farbe und Form:LiquidMolekulargewicht:145.8 kDaOtilimab
CAS:Otilimab, a humanized monoclonal antibody, blocks GM-CSF to reduce inflammation and may treat severe COVID-19 pneumonia.
Reinheit:> 95%Farbe und Form:LiquidMolekulargewicht:142.22 kDaPLX647 dihydrochloride
CAS:PLX647 dihydrochloride: potent FMS/KIT inhibitor (IC50: 28/16 nM), highly selective, limited FLT3/KDR activity, oral use.Formel:C21H19Cl2F3N4Farbe und Form:SolidMolekulargewicht:455.31AMG-820
AMG-820 is a human antibody targeting CSF-1R, inhibiting the binding of ligands CSF1 and IL34, and preventing subsequent ligand-induced receptor activation. For AMG-820's isotype control, refer to [Human IgG2 kappa, Isotype Control].Farbe und Form:Odour LiquidCSF1R-IN-17
CSF1R-IN-17 (compound 9) is a potent, selective antagonist of CSF1R, exhibiting an inhibition concentration half-maximum (IC50) of 0.2 nM.Formel:C20H25N5O2Reinheit:98%Farbe und Form:SolidMolekulargewicht:367.44
