Ubiquitinylierung
Ubiquitinierungsinhibitoren sind Verbindungen, die in den Prozess der Ubiquitinierung eingreifen, bei dem Proteine mit Ubiquitinmolekülen markiert werden, um vom Proteasom abgebaut zu werden. Diese Inhibitoren sind entscheidend für das Studium des Proteinumsatzes, der Signaltransduktion und der Regulation verschiedener zellulärer Prozesse. Die Ubiquitinierung spielt eine Schlüsselrolle bei vielen Krankheiten, einschließlich Krebs, neurodegenerativen Störungen und Funktionsstörungen des Immunsystems. Durch die Modulation der Ubiquitinierung können diese Inhibitoren Einblicke in Krankheitsmechanismen bieten und neue Wege für therapeutische Interventionen eröffnen. Bei CymitQuimica bieten wir eine breite Auswahl hochwertiger Ubiquitinierungsinhibitoren zur Unterstützung Ihrer Forschung in Zellbiologie, Proteomik und Wirkstoffentwicklung an.
Unterkategorien von "Ubiquitinylierung"
70 Produkte aus dem Bereich "Ubiquitinylierung" gefunden
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WS-383
CAS:WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).Formel:C18H21Cl2N9S2Reinheit:98.46%Farbe und Form:SolidMolekulargewicht:498.46Ref: TM-T13349
1mg46,00€2mg58,00€5mg87,00€10mg144,00€25mg283,00€50mg558,00€100mg797,00€500mg1.634,00€1mL*10mM (DMSO)97,00€ML-792
CAS:ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor.Cost-effective and quality-assured.Formel:C21H23BrN6O5SReinheit:99.32% - 99.82%Farbe und Form:SolidMolekulargewicht:551.41Ref: TM-T16102
1mg87,00€2mg113,00€5mg177,00€10mg260,00€25mg409,00€50mg560,00€100mg800,00€1mL*10mM (DMSO)225,00€NSC232003
CAS:NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.Formel:C6H7N3O3Reinheit:97.72%Farbe und Form:SolidMolekulargewicht:169.14TAS4464 hydrochloride
CAS:TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).Formel:C21H24ClFN6O6SReinheit:98.61% - 98.96%Farbe und Form:SolidMolekulargewicht:542.97Ref: TM-T13090
1mg66,00€5mg144,00€10mg227,00€25mg455,00€50mg753,00€100mg1.301,00€1mL*10mM (DMSO)167,00€MF-094
CAS:MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Formel:C30H37N3O4SReinheit:99.93%Farbe und Form:SolidMolekulargewicht:535.7Ref: TM-T12024
1mg43,00€5mg87,00€10mg144,00€25mg283,00€50mg454,00€100mg655,00€200mg934,00€1mL*10mM (DMSO)104,00€UP163
CAS:UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.Formel:C20H15ClN2O5SFarbe und Form:SolidMolekulargewicht:430.86SAE-IN-2
SAE-IN-2 (compound 6) is a potent inhibitor of sumoylation-activating enzyme (SAE) with an IC50 value of 27.8 nM.Formel:C27H30ClN5O5S2Molekulargewicht:603.13769UP12
CAS:UP12 enhances ATPase activity by activating valosin-containing protein (VCP), with an EC50 of 2.57 μM.Formel:C23H16ClN3O3SFarbe und Form:SolidMolekulargewicht:449.91Post-Translational Modification Compound Library
Contains xnum active small molecules for research related to post-translational modifications (PTMs);
Farbe und Form:Odour SolidRef: TM-L1620
1mgNachfragen30μL*10mM (DMSO)Nachfragen50μL*10mM (DMSO)Nachfragen100μL*10mM (DMSO)Nachfragen250μL*10mM (DMSO)NachfragenUSP8-IN-2
CAS:USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.
Formel:C19H20ClF3N4OSReinheit:99.92%Farbe und Form:SolidMolekulargewicht:444.9Rugonersen sodium
CAS:Rugonersen sodium is a locked nucleic acid (LNA)-modified antisense oligonucleotide (ASO) designed to reduce the silencing of ubiquitin protein ligase E3A (UBE3A). Angelman syndrome (AS) refers to a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, and Rugonersen has been studied for its potential use in the treatment of AS.Formel:C204H235N63Na19O109P19S19Molekulargewicht:6948.00Skp2 inhibitor 3
Skp2 inhibitor 3 (E35), a potent antitumor agent, acts as a robust inhibitor of S-phase kinase-associated protein 2 (SKP2) with an IC50 of 4.86 μM for Skp2-Cks1 binding. It significantly suppresses colony formation and migration, while inducing cell cycle arrest in the S-phase.Farbe und Form:Odour SolidRNF5 agonist 1
CAS:RNF5 agonist 1 (analog-1), a structural analog of the RNF5 inhibitor inh-02, is a potent RNF5 agonist. In CFBE41o- cells expressing F508del-CFTR, RNF5 agonist 1 enhances the ubiquitination of ATG4B.Formel:C22H18N4SFarbe und Form:SolidMolekulargewicht:370.47UP158
CAS:UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.Formel:C17H17ClN4O2Farbe und Form:SolidMolekulargewicht:344.8dCeMM3
CAS:dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.
Formel:C14H11ClN4OSReinheit:98.48% - 99.41%Farbe und Form:SolidMolekulargewicht:318.78Cbl-b-IN-18
Cbl-b-IN-18 (compound 51) is an inhibitor of the E3 ubiquitin ligase Cbl-b, effectively blocking Cbl-b phosphorylation with an IC50 of less than 100 nM.Formel:C33H31F4N7OMolekulargewicht:617.25262Ubiquitination Compound Library
A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；Farbe und Form:Odour SolidRef: TM-L8600
1mgNachfragen30μL*10mM (DMSO)Nachfragen50μL*10mM (DMSO)Nachfragen100μL*10mM (DMSO)Nachfragen250μL*10mM (DMSO)NachfragenCbl-b-IN-15
Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ubiquitin ligase Cbl, demonstrating an IC50 of 15 nM. Cbl-b refers to Casitas B-lineage Lymphoma proto-oncogene-b, which can inhibit the activation of T cells, natural killer (NK) cells, and B cells. Cbl-b-IN-15 can activate T cell function with an EC50 of 0.41 μM.Formel:C27H27N5O3Molekulargewicht:469.21139MSC1094308
CAS:MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.Formel:C29H29F3N2Farbe und Form:SolidMolekulargewicht:462.55ML241 hydrochloride
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-Formel:C23H25ClN4OReinheit:99.91% - 99.96%Farbe und Form:SolidMolekulargewicht:408.92
