DUB
DUB-Inhibitoren zielen auf Deubiquitinylasen ab, Enzyme, die Ubiquitin-Moleküle von Proteinen entfernen und dadurch die Stabilität, Lokalisation und Aktivität von Proteinen in der Zelle regulieren. Deubiquitinylasen spielen eine wesentliche Rolle in verschiedenen zellulären Prozessen, einschließlich der Regulierung des Zellzyklus, der DNA-Reparatur und der Immunantworten. Eine Fehlregulation der DUB-Aktivität wird mit Krebs, neurodegenerativen Erkrankungen und Virusinfektionen in Verbindung gebracht. Inhibitoren von DUBs können diese Prozesse modulieren und bieten potenzielle therapeutische Ansätze für diese Erkrankungen. Bei CymitQuimica bieten wir DUB-Inhibitoren an, um Ihre Forschung in den Bereichen Proteinhomöostase, Onkologie und Neurobiologie zu unterstützen.
89 Produkte aus dem Bereich "DUB" gefunden
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IU1-47
CAS:IU1-47 是一种特异性 USP14抑制剂，IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5， IC50为 20 μM。Formel:C19H23ClN2OReinheit:98.94%Farbe und Form:SolidMolekulargewicht:330.85Ref: TM-T15604
1mg34,00€5mg64,00€10mg109,00€25mg222,00€50mg358,00€100mg593,00€200mg830,00€1mL*10mM (DMSO)70,00€C527
CAS:C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).Formel:C17H8FNO3Reinheit:97.22%Farbe und Form:SolidMolekulargewicht:293.25MF-094
CAS:MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Formel:C30H37N3O4SReinheit:99.93%Farbe und Form:SolidMolekulargewicht:535.7Ref: TM-T12024
1mg43,00€5mg87,00€10mg144,00€25mg283,00€50mg454,00€100mg655,00€200mg934,00€1mL*10mM (DMSO)104,00€HBX 19818
CAS:HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).Formel:C25H28ClN3OReinheit:97.71%Farbe und Form:SolidMolekulargewicht:421.96Ref: TM-T15464
1mg35,00€5mg80,00€10mg111,00€25mg177,00€50mg253,00€100mg353,00€200mg502,00€1mL*10mM (DMSO)89,00€GRL0617
CAS:GRL0617 is a selective and competitive SARS-CoVPLpro and deubiquitinase noncovalent inhibitor(IC50 : 0.6 μM, Ki : 0.49 μM).Formel:C20H20N2OReinheit:99.31%Farbe und Form:SolidMolekulargewicht:304.39Ref: TM-T11464
1mg34,00€5mg74,00€10mg105,00€25mg178,00€50mg313,00€100mg500,00€500mg1.063,00€1mL*10mM (DMSO)82,00€EN523
CAS:EN523 targets non-catalytic allosteric cysteine C23 in K48 ubiquitin-specific deuquitinase OTUB1.Formel:C12H14N2O3Reinheit:99.5%Farbe und Form:SolidMolekulargewicht:234.25Ref: TM-T9884
1mg34,00€5mg66,00€10mg99,00€25mg222,00€50mg356,00€100mg570,00€200mg800,00€1mL*10mM (DMSO)67,00€Subquinocin
Subquinocin is a CYLD inhibitor that suppresses deubiquitinating enzymes (DUB) of the USP family. By inhibiting CYLD, Subquinocin enhances the activation of the NF-κB and IFN pathways. Additionally, Subquinocin facilitates the activation of IRF3 and/or IRF7 in the RIG-I-mediated interferon pathway.Formel:C20H27N3O4SFarbe und Form:SolidMolekulargewicht:405.17223T20-M
T20-M is a precursor peptide with strong binding affinity for UBE2C.Formel:C87H140N22O26SFarbe und Form:SolidMolekulargewicht:1942.24BAY-728
BAY-728 serves as a negative control for BAY-805, a potent and selective inhibitor of USP21 [1].Formel:C24H28F3N5O2SFarbe und Form:SolidMolekulargewicht:507.57MS7131
MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.Farbe und Form:Odour SolidGK16S
GK16S, a UCHL1 chemogenomic probe, serves as a complementary tool to GK13S for the investigation of UCHL1 function in cellular studies [1].Formel:C11H15N3OFarbe und Form:SoildMolekulargewicht:205.12151USP7-IN-15
USP7-IN-15 (compound J21) is an inhibitor of USP7, exhibiting an IC50 value of 41.35 ± 2.16 nM.Farbe und Form:Odour SolidUBD1031
UBD1031 exhibits strong affinity for the ubiquitin-binding domain (UBD) of USP16, with a dissociation constant (KD) of 48 nM. It inhibits the interaction between USP16 and ISG15, displaying an effective concentration (EC50) of 1.7 nM. UBD1031 can serve as a chemical probe for investigating USP16 UBD.Farbe und Form:Odour SolidUSP7 Ligand-Linker Conjugates 1
USP7Ligand-Linker Conjugates 1 is a Target Protein Ligand-Linker Conjugate comprising a USP7 ligand and a PROTAC linker, capable of recruiting E3 ligase. It is utilized in the synthesis of PROTACUSP7 Degrader-1.Farbe und Form:Odour SolidGK13S
G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.Formel:C21H22N6O2Farbe und Form:SolidMolekulargewicht:390.44USP7-IN-10 hydrochloride
USP7-IN-10 hydrochloride, also known as compound 1, is a potent inhibitor of the enzyme ubiquitin-specific protease 7 (USP7), exhibiting an IC50 value of 13.39Formel:C26H30Cl2N4O3SFarbe und Form:SolidMolekulargewicht:549.51Ubiquitination Compound Library
A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；Farbe und Form:Odour SolidRef: TM-L8600
1mgNachfragen30μL*10mM (DMSO)Nachfragen50μL*10mM (DMSO)Nachfragen100μL*10mM (DMSO)Nachfragen250μL*10mM (DMSO)NachfragenJAMM protein inhibitor 2
CAS:JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.Formel:C21H26N2O2Reinheit:98.57%Farbe und Form:SolidMolekulargewicht:338.44USP7-IN-16
CAS:USP7-IN-16 (Compound 61) is a selective inhibitor of USP7, with IC50 values of 5.5 nM in the FLINT assay and 2.1 nM in MM.1S cells. This compound exhibits antitumor activity in mice and holds potential for research in the field of oncology.Formel:C43H45N7O6SFarbe und Form:SolidMolekulargewicht:787.93USP8-IN-3
CAS:USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.Formel:C18H18F3N5O2SReinheit:99.79%Farbe und Form:SolidMolekulargewicht:425.43Ref: TM-T67873
1mg34,00€5mg60,00€10mg92,00€25mg195,00€50mg311,00€100mg449,00€500mg888,00€1mL*10mM (DMSO)79,00€
