Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Ref. 01-4011369

Produktinformation

• Name: Suc-Leu-Leu-Val-Tyr-AMC
• Synonyme: Chymotrypsin Substrate III, Fluorogenic, N-succinyl-leu-leu-val-tyr 7-amido-4-*methylcouma, Succinyl-leucyl-leucyl-valyl-tyrosyl-methylcoumarinamide, Llvy-mca, N-Succinyl-leu-leu-val-tyr-7-amido-4-methylcoumarin, Sllvt-mca, Suc-leu-leu-val-tyr-7-amino-4-methylcoumarin, Suc-leu-leu-val-tyr-mca, Suc-llvy-mca, L-Tyrosinamide, N-(3-carboxy-1-oxopropyl)-L-leucyl-L-leucyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, N-(3-carboxypropanoyl)leucylleucyl-L-valyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-tyrosinamide

Beschreibung

The fluorogenic substrate Suc-LLVY-AMC is used for measuring the chymotrypsin-like activity of the 20S proteasome, in combination with e.g. Bz-VGR-AMC (for assaying its trypsin-like activity) and Z-LLE-AMC (for determining its PGPH activity). Suc-LLVY-AMC is also cleaved by a chymotrypsin-like enzyme from sperm extract of the ascidian Halocynthia roretzi, a strong inhibitor of fertilization. The substrate has also been used to analyze the chymotrypsin-like activity of trypsins as well as chymase from rat mast cells. Furthermore, Suc-LLVY-AMC is a substrate for carboxypeptidase Y, proteinase yscE (kexin), ingensin, as well as for porcine calpain isozymes I and II and for papain.

• Marke: Bachem

Chemische Eigenschaften

• Molekulargewicht: 763.89
• Formel: C₄₀H₅₃N₅O₁₀
• Reinheit: > 98%
• Farbe/Form: White