Endotoxin Inhibitor

CAS: 147396-10-9

Ref. 01-4014453

Produktinformation

• Name: Endotoxin Inhibitor
• Synonyme: K-T-K-C-K-F-L-K-K-C, H-Lys-Thr-Lys-Cys-Lys-Phe-Leu-Lys-Lys-Cys-OH (Disulfide bond), H-Lys-Thr-Lys-Cys-Lys-Phe-Leu-Lys-Lys-Cys-Oh
• CAS: 147396-10-9

Beschreibung

The cyclic peptide KTKCKFLKKC has ben shown to form a strong complex with lipid A, the toxic component of the endotoxin lipopolysaccharide (LPS) with Ka = 0.56 · 107 M-1. It detoxifies LPS in vitro and prevents LPS-induced cytokine release and lethality in vivo. Furthermore, it shows neither antibiotic activity nor toxicity and might therefore be useful in the prophylaxis and treatment of LPS-mediated diseases. KTKCKFLKKC bears a structural resemblance to the peptide antibiotic and endotoxin inhibitor polymyxin B. It could be of use as an adjuvant for antibiotic therapy.

• Marke: Bachem

Chemische Eigenschaften

• Molekulargewicht: 1224.6
• Formel: C₅₅H₉₇N₁₅O₁₂S₂
• Reinheit: 98.8%
• Farbe/Form: White Powder