Cyclo(-D-Tyr-Arg-Gly-Asp-Cys(carboxymethyl)-OH) sulfoxide

CAS: 143120-27-8

Ref. 01-4020214

Produktinformation

• Name: Cyclo(-D-Tyr-Arg-Gly-Asp-Cys(carboxymethyl)-OH) sulfoxide
• Synonyme: G 4120, Cyclo(S-acetyl-tyrosyl-arginyl-glycyl-aspartyl-cysteinyl-OH) (sulfoxide), Cyclo-S-Ac-tyr-arg-gly-asp-cys-OH (sulfoxide), Cyclo-S-Ac-tyr-rgd-cys-OH (sulfoxide), L-Cysteine, N-(mercaptoacetyl)-D-tyrosyl-L-arginylglycyl-L-alpha-aspartyl-, cyclic (1-5)-disulfide, S-oxide, (3R,6S,12S,15R)-6-(carboxymethyl)-12-{3-[(diaminomethylidene)amino]propyl}-15-(4-hydroxybenzyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacyclooctadecane-3-carboxylic acid 1-oxide, Cyclo(-D-Tyr-Arg-Gly-Asp-Cys (Carboxymethyl)-Oh) Sulfoxide

Beschreibung

This sulfur-bridged cyclic RGD peptide is a potent inhibitor of the binding of glycoprotein IIb/IIIa to fibrinogen with an IC₅₀ of 1.5 nM. Furthermore, it is a highly potent inhibitor of fibrinogen-mediated platelet aggregation (IC₅₀ = 0.15 µM). Its antithrombotic activity in vivo may render this compound useful in the treatment of arterial thromboembolic diseases.

• Marke: Bachem

Chemische Eigenschaften

• Molekulargewicht: 668.69
• Formel: C₂₆H₃₆N₈O₁₁S
• Farbe/Form: White