H-Cys-psi(CH₂NH)Val-psi(CH₂NH)Phe-Met-OH

CAS: 149759-96-6

Ref. 01-4025336

Produktinformation

• Name: H-Cys-psi(CH₂NH)Val-psi(CH₂NH)Phe-Met-OH
• Synonyme: B581, <span class="text-smallcaps">L</smallcap>-Methionine, N-[(2S)-2-[[(2R)-2-amino-3-mercaptopropyl]amino]-3-methylbutyl]-<smallcap>L</span>-phenylalanyl-, <span class="text-smallcaps">L</smallcap>-Methionine, N-[N-[2-[(2-amino-3-mercaptopropyl)amino]-3-methylbutyl]-<smallcap>L</span>-phenylalanyl]-, [S-(R*,S*)]-, B 581, Cys-((R))-Val-((R))-Phe-Met, Ftase Inhibitor I, H-Cys-(R)-Val-(R)-Phe-Met-Oh, N-[(2S)-2-[[(2R)-2-Amino-3-mercaptopropyl]amino]-3-methylbutyl]-<span class="text-smallcaps">L</smallcap>-phenylalanyl-<smallcap>L</span>-methionine, N-[(2S)-2-{[(2R)-2-amino-3-sulfanylpropyl]amino}-3-methylbutyl]-L-phenylalanyl-L-methionine, N-[(S)-2-((R)-2-Amino-3-Mercapto-Propylamino)-3-Methyl-Butyl]-Phe-Met-Oh, N-[2(S)-(2(R)-2-Amino-3-Mercaptopropylamino)-3-Methylbutyl]-L-Phenylalanyl-L-Methionine, N-[2(S)-[2(R)-Amino-3-Mercaptopropylamino]-3-Methyl-Butyl]-Phe-Met, N-[2(S)-[2(R)-Amino-3-Mercaptopropylamino]-3-Methylbutyl]-Phe-Met-Oh

Beschreibung

B581, Cys-psi(CH₂NH)-Val- psi[CH₂NH]-Phe-Met is a farnesyltransferase (FTase) inhibitor of special stability and membrane permeability. Due to its high selectivity, B581 is more than 30-fold more active against FTase (IC₅₀ = 21 nM in vitro) than against geranylgeranyltransferase (GGTase). Inhibitors of the farnesyltransferase are potential candidates for the development of anticancer drugs.

• Marke: Bachem

Chemische Eigenschaften

• Molekulargewicht: 470.7
• Formel: C₂₂H₃₈N₄O₃S₂
• Reinheit: 95.7%