(Glu²)-TRH

CAS: 85541-78-2

Ref. 01-4026102

Produktinformation

• Name: (Glu²)-TRH
• Synonyme: Fertilization-Promoting Peptide, Pyroglutamyl-glutamyl-proline amide, Fertilization promoting peptide, Glp-glu-pronh2, Pglu-glu-pronh2, Pyroglutamyl-glutamyl-prolinamide, Pyroglutamyl-glutamyl-prolineamide, L-Prolinamide, 5-oxo-L-prolyl-L-alpha-glutamyl-, 5-oxo-L-prolyl-L-alpha-glutamyl-L-prolinamide, (Glu2)-TRH, Pyr-Glu-Pro-NH2

Beschreibung

Fertilization-promoting peptide (FPP), a TRH analog, was previously purified and characterized from both rabbit prostate and human semen. Nanomolar concentrations of this peptide have been shown to enhance capacitation of mouse epididymal spermatozoa with a concomitant increase in fertilizing ability. It was also detected in the thyroid gland. According to a study of Nguyen et al. Pyr-Glu-Pro-NH₂ opposes the cholinergic effect of TRH in the mammalian CNS: Co-perfusion with an equivalent of TRH in the rat hippocampus resulted in a significant attenuation of TRH-induced acetylcholine release.

• Marke: Bachem

Chemische Eigenschaften

• Molekulargewicht: 354.36
• Formel: C₁₅H₂₂N₄O₆
• Reinheit: 98.6%
• Farbe/Form: Whitish Powder