Fmoc-Cys(SASRIN™ resin)-OH (200-400 mesh, 0.3-0.6 mmol/g)

Ref. 01-4026902

Produktinformation

• Name: Fmoc-Cys(SASRIN™ resin)-OH (200-400 mesh, 0.3-0.6 mmol/g)

Beschreibung

This resin has been developed to allow C-terminal modification of cysteine-containing peptides. Fmoc-protected cysteine is linked to SASRINTM-resin by its thiol moiety, which thus is already protected. After derivatization of the carboxylic acid (and, if desired, standard Fmoc-SPPS) lthe modified cysteine derivative can be cleaved with TFA/water/triisopropylsilane (94:4:2, v/v/v) from the SASRINTM-resin. Extending the peptide chain at the C-terminus can be achieved by activation of the side-chain linked cysteine carboxylic acid and coupling to additional amino acids. Cys linked to a resin by its thiol function was oxidized with MCPBA after esterification and Na-modification (Yamada et al.). DBU-induced elimination yielded dehydroalanine derivatives.

• Marke: Bachem

Chemische Eigenschaften

• Molekulargewicht: n/a
• Formel: na
• Farbe/Form: Beige Powder