Diphenyldiazomethane resin (200-400 mesh, 0.7-1.3 mmol/g)

Ref. 01-4027172

Produktinformation

• Name: Diphenyldiazomethane resin (200-400 mesh, 0.7-1.3 mmol/g)
• Synonyme: Ph-CN₂-Ph-polymer

Beschreibung

Diphenyldiazomethane was used industrially for producing benzhydryl esters (diphenylmethyl esters) of b-lactam antibiotics. This "polymeric diphenyldiazomethane" readily reacts with carboxylic acids, e.g. Fmoc-amino acids, which need not to be activated. Products can be cleaved from this very acid-sensitive resin derivative with 1-5 % TFA in dichloromethane. Fmoc-a-amino alcohols can be anchored to PDDM in the presence of BF3 etherate. As the resulting benzhydryl ethers can be cleaved with 1% TFA/DCM, fully protected peptide alcohols can be obtained.

• Marke: Bachem

Chemische Eigenschaften

• Molekulargewicht: n/a
• Formel: na
• Farbe/Form: Purple Powder