GLP-1 (9-36) amide (human, bovine, guinea pig, mouse, porcine, rat)

CAS: 161748-29-4

Ref. 01-4027697

Produktinformation

• Name: GLP-1 (9-36) amide (human, bovine, guinea pig, mouse, porcine, rat)
• Synonyme: Preproglucagon (100-127) amide (human, bovine, guinea pig, mouse, porcine, rat), Proglucagon (80-107) Amide (Human, Bovine, Guinea Pig, Mouse, Porcine, Rat), Preproglucagon (100-127) Amide (Human, Bovine, Guinea Pig, Mouse, Porcine, Rat), H-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Nh2, Glucagon-Like Peptide 1 (9-36) Amide (Human, Bovine, Guinea Pig, Mouse, Porcine, Rat)

Beschreibung

Glucagon-like peptide-1 (GLP-1) is efficiently degraded by the enzyme dipeptidyl peptidase IV (DPP IV), yielding the major metabolite GLP-1 (9-36) amide. GLP-1 (9-36) amide does not affect glucose disposal in mice either in the presence or absence of intact GLP-1 receptors or in the presence or absence of stimulated insulin levels. This suggests that the GLP-1 metabolite is not involved in the regulation of glucose homeostasis. Elahi et al. have shown that this GLP-1 metabolite acts as a weak insulinotropic agent and inhibits hepatic glucose production.

• Marke: Bachem

Chemische Eigenschaften

• Molekulargewicht: 3089.46
• Formel: C₁₄₀H₂₁₄N₃₆O₄₃
• Reinheit: ≥ 98%
• Farbe/Form: White Powder