Orexin A (human, mouse, rat)

CAS: 205640-90-0

Ref. 01-4028262

Produktinformation

• Name: Orexin A (human, mouse, rat)
• Synonyme: Hypocretin-1 (human, mouse, rat), OrexinA (human), Bovine orexin A, Human orexin A, Mouse orexin A, Orexin A (swine), Pig orexin A, Rat orexin A, Pyr-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-Nh2

Beschreibung

Orexin A (OXA, hypocretin-1) is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of orexin A to rats stimulated food consumption in a dose-dependent manner. The effect persisted at 4 h after injection, as orexin A seems to be resistant to peptidases. Orexin A specifically binds a G protein-coupled receptor, OX₁R (IC₅₀ = 20 nM to displace 50 % of radiolabeled orexin A bound to this receptor). Orexin A produced in the amygdala induces wakefulness and plays a role in the induction of human emotions. Narcolepsy has been associated with orexin deficiency. The peptide also corresponds to bovine, canine, ovine, and porcine orexin A.

• Marke: Bachem

Chemische Eigenschaften

• Molekulargewicht: 3561.16
• Formel: C₁₅₂H₂₄₃N₄₇O₄₄S₄
• Reinheit: 95.9%
• Farbe/Form: White Lyophilisate