PACAP-27 (human, mouse, ovine, porcine, rat)

CAS: 127317-03-7

Ref. 01-4031084

Produktinformation

• Name: PACAP-27 (human, mouse, ovine, porcine, rat)
• Synonyme: Pituitary Adenylate Cyclase Activating Polypeptide-27 (human, mouse, ovine, porcine, rat), Pituitary Adenylate Cyclase Activating Polypeptide (1-27) amide (human, ovine, rat), H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2, PACAP 27 Amide, Ovine

Beschreibung

PACAP-38 and its N-terminal fragment PACAP-27 are neuropeptides originally isolated from ovine hypothalamus, but also found in humans and rats. Both PACAP-27, which shows considerable homology with vasoactive intestinal polypeptide (VIP), and PACAP-38 stimulate adenylate cyclase much more potently than VIP. Specific PACAP receptors have been identified in different tissues and cell lines.Kojro et al. observed that the PAC1 agonists PACAP-27 and PACAP-38 strongly increased the activity of α-secretase, thus promoting the non-amyloidogenic processing of amyloid precursor protein.

• Marke: Bachem

Chemische Eigenschaften

• Molekulargewicht: 3147.65
• Formel: C₁₄₂H₂₂₄N₄₀O₃₉S
• Reinheit: ≥ 97%
• Farbe/Form: White