PACAP-38 (human, mouse, ovine, porcine, rat)

CAS: 124123-15-5

Ref. 01-4031157

Produktinformation

• Name: PACAP-38 (human, mouse, ovine, porcine, rat)
• Synonyme: Pituitary Adenylate Cyclase Activating Polypeptide-38 (human, mouse, ovine, porcine, rat), H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2

Beschreibung

Kojro et al. observed that the PAC1 agonists PACAP-27 (H-1172) and PACAP-38 strongly increased the activity of α-secretase. Upregulation of this APP-degrading enzyme promotes the non-amyloidogenic processing of APP, i.e. reduces the production of Aβ40/42, and thus may help to prevent Alzheimer’s disease. Nasally applied PACAP-38 in APP[V717I]-transgenic mice additionally enhanced the production of the Aβ-degrading enzyme neprilysin via induction of somatostatin.

• Marke: Bachem

Chemische Eigenschaften

• Molekulargewicht: 4534.32
• Formel: C₂₀₃H₃₃₁N₆₃O₅₃S
• Reinheit: 97.6%
• Farbe/Form: White