(Val³⁴)-Amyloid β-Protein (1-40)

CAS: 1678415-83-2

Ref. 01-4089805

Produktinformation

• Name: (Val³⁴)-Amyloid β-Protein (1-40)
• Synonyme: Amyloid β-Protein (1-40) L34V
• Marke: Bachem

Beschreibung

Cerebral amyloid angiopathy (CAA) is a common finding in Alzheimer’s disease in which amyloid-Aβ vascular deposits are featured in >80% of the cases. Mutations in the positions 21-23 (e.g. Dutch mutation E22Q) are primarily associated with CAA, although they manifest with strikingly different clinical phenotypes: cerebral hemorrhage or dementia. The Piedmont L34V Aβ mutant, located outside this hot spot, shows a similar hemorrhagic phenotype, albeit less aggressive than the widely studied Dutch variant.

Chemische Eigenschaften

• Molekulargewicht: 4315.84
• Formel: C₁₉₃H₂₉₃N₅₃O₅₈S
• Reinheit: >95%
• Farbe/Form: White Powder