α-Synuclein (34-45) (human)

CAS: 2170181-52-7

Ref. 01-4107367

Produktinformation

• Name: α-Synuclein (34-45) (human)
• Marke: Bachem
• Beschreibung: The Parkinson’s disease-associated protein α-synuclein (α-syn) is not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft dependent process. Two distinct cholesterol-binding domains in α-synuclein were identified by Fantini and coworkers. The tilted peptide of α-synuclein (67-78) bound cholesterol with high affinity and was toxic for cultured astrocytes. A cholesterol recognition consensus motif with lower affinity for cholesterol and devoid of toxicity, is encased in the glycosphingolipid-binding domain (34-45) of α-synuclein. The authors propose that the association of α-synuclein with lipid rafts involves both the binding of α-synuclein (34-45) to glycosphingolipids, and the interaction of α-synuclein (67-78) with cholesterol.

Chemische Eigenschaften

• Molekulargewicht: 1308.52
• Formel: C₅₉H₁₀₁N₁₅O₁₈
• Reinheit: 97.8%
• Farbe/Form: White Powder