Chikungunya Virus Envelope 1 & 2 Antigen Mouse Monoclonal Antibody

Ref. 3D-AZ1269-R

Produktinformation

• Name: Chikungunya Virus Envelope 1 & 2 Antigen Mouse Monoclonal Antibody
• Marke: Biosynth
• Beschreibung: A Mouse Monoclonal Antibody complementary to recombinant Chikungunya envelope 1 (E1) and 2 (E2) proteins, which is available as the immunoglobulin subclass IgG1. The product has been purified by ion exchange chromatography and is presented as a liquid in 0.015M potassium phosphate, 0.85% NaCl, pH 7.2.</p> <p>Transmitted by mosquito vectors, Chikungunya is a positive-stranded RNA, alpha virus infecting human musculoskeletal tissues. The two glycoproteins E1 and E2 of the Chikungunya virus, to which this Mab is complementary, are responsible for viral entry into host cells and both contain a transmembrane domain. Furthermore E2 has the three globular domains A, B and C which are linked by a &beta;-ribbon connector region. While E2 is essential for mediating viral attachment, E1&rsquo;s &beta;-sheet structure and class II viral glycoproteins: DI, DII and DIII domains enable the virus to fuse with the host&rsquo;s membrane. This primarily occurs through the insertion of the DII domain&rsquo;s fusion loop into the host&rsquo;s cell membrane.</p> <p>Together E1 and E2 form a viral spike protein which when binding with high affinity to host alphavirus receptors such as Mxra8, allow this receptor to be inserted into E1 and E2. This results in Mxra8 contact between E2&rsquo;s A and B domains and E1&rsquo;s fusion loop. Neutralising antibodies can target these domains, in particular A and B domains within E2, hence preventing viral attachment to host cells. Consequently this antibody could be used to investigate possible treatments to combat Chikungunya virus. Another potential application of this product could be used in antibody and antigen interaction dependent assays to detect the presence of the Chikungunya virus