Afatinib dimaleate

CAS: 850140-73-7

Ref. 3D-BA162012

Produktinformation

• Name: Afatinib dimaleate
• Synonyme: 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-, (2Z)-2-butenedioate (1:2), BIBW2992 DiMaleate, Bibw 2992Ma2, Bibw2992-Ma2

Beschreibung

Irreversible blocker of three members of the ErbB family (ErbB1, ErbB2/HER2, and ErbB4) with IC50 in nanomolar range. The compound binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling, inhibits cellular growth and promotes apoptosis. Afatinib has been used for the treatment of tyrosine kinase inhibitor-resistant tumours with mutations in ErbB genes, especially for deletions in exon 19 and single nucleotide substitutions in exon 21. It has been used for treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer, colorectal cancer, etc.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 718.08 g/mol
• Formel: C₂₄H₂₅ClFN₅O₃·C₈H₈O₈
• Reinheit: Min. 95%
• Farbe/Form: Solid