16β-Hydroxy dhea
CAS: 1159-68-8
Ref. 3D-BAA15968
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Produktinformation
- 3beta,16beta-Dihydroxyandrost-5-en-17-one
- Androst-5-En-17-One, 3,16-Dihydroxy-, (3Beta,16Beta)-
Dhea is a steroid hormone that is formed in the adrenal glands and brain. Dhea has been shown to have receptor binding activity in human cells, which may be due to its ability to bind to glucocorticoid receptors. Dhea also binds to mineralocorticoid receptors and has been shown to increase blood pressure. Dhea can be conjugated with glucuronic acid or sulfate, which will affect its distribution in the body. The conjugates are hydrolyzed by esterases or glucuronidases and release dhea into the circulation. The major route of elimination of dhea is through the kidneys where it undergoes glomerular filtration and tubular secretion. In infants, dhea is transferred from maternal milk to the infant's blood stream via diffusion across the mammary gland barrier. Mass spectrometry-based assays have been developed for determining plasma concentrations of dhea, estradiol, and progesterone in humans.
Chemische Eigenschaften
Technische Anfrage zu: 3D-BAA15968 16β-Hydroxy dhea
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