CHIR 99021 hydrochloride

CAS: 1797989-42-4

Ref. 3D-BC162488

Produktinformation

• Name: CHIR 99021 hydrochloride

Beschreibung

Potent and selective inhibitor of the glycogen synthase kinase GSK-3. Promotes cell renewal in embryonic stem cells by modulating Notch, MAPK and TGF-β signalling pathways, which are involved in pluripotency. It also affects the Wnt/β-catenin pathway and alters expression of genes coding for proteins, epigenetic regulatory elements and non-coding RNAs. The combination of CHIR 99021 and basic fibroblast growth factor (bFGF) allows long-term self-renewal in adult mouse retinal progenitor cells.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 501.8 g/mol
• Formel: C₂₂H₁₈Cl₂N₈·HCl
• Reinheit: Min. 95%