Clozapine - Bio-X ™

CAS: 5786-21-0

Ref. 3D-BC164328

Produktinformation

• Name: Clozapine - Bio-X ™
• Synonyme: 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine HF-1854
• Marke: Biosynth

Beschreibung

Clozapine, a dibenzodiazepine, demonstrates antagonistic activity at the dopamine receptors, further binding to serotonin (5-HT1A, 5-HT2A-C, 5-HT6, 5-HT7), alpha 1 and 2 adrenergic, histamine 1 and M1-M5 muscarinic receptors. In particular, its partial 5-HT1A agonist behaviour, its low affinity for the D2 Dopamine receptors and its antagonistic activity at 5-HT2A receptors, are properties, which make it useful as an antipsychotic drug. The FDA has approved Clozapine for use in the alleviation of symptoms in treatment-resistant schizophrenia patients, such as the risk of self-harm. Although not yet approved by the FDA, Clozapione exerts positive effects in Parkinson’s disease and bipolar disorder treatments. However, Clozapione is not currently a first line-therapy option, as it may cause agranulocytosis and other side effects such as orthostatic hypotension and hypersalivation.

Chemische Eigenschaften

• Molekulargewicht: 326.82 g/mol
• Formel: C₁₈H₁₉ClN₄
• Reinheit: Min. 95%
• Farbe/Form: Yellow Powder