PF 05175157

CAS: 1301214-47-0

Ref. 3D-BCC21447

Produktinformation

• Name: PF 05175157
• CAS: 1301214-47-0

Beschreibung

PF 05175157 is a potent small molecule, orally active inhibitor of fatty acid synthase (FAS) that causes hepatocyte steatosis in vitro and in vivo. PF 05175157 is also an inhibitor of the enzyme stearoyl-CoA desaturase 1 (SCD1), which converts saturated to monounsaturated fatty acids. The compound has been shown to reduce liver and body weight gain in mice fed a high-fat diet, as well as to improve dyslipidemia and hepatic steatosis. PF 05175157 has been evaluated clinically for the treatment of obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver disease.
PF 05175157 was granted orphan drug designation for the treatment of pediatric chronic kidney disease by the FDA on June 6, 2015.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 405.49 g/mol
• Formel: C₂₃H₂₇N₅O₂
• Reinheit: Min. 95%