Filipin III

CAS: 480-49-9

Ref. 3D-BF162726

Produktinformation

• Name: Filipin III
• Synonyme: (17E,19E,21E,23E,25E)-4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one, (17Z,19E,21E,23E,25E)-4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one, (3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,16,27-octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one, 14-Deoxylagosin, 15-Deoxylagosin, 1′,26-Dihydroxyfilipin I, 1′-Hydroxyfilipin II, 1′-epi-Filipin IV, 4,6,8,10,12,14,16,27-Octahydroxy-3-(1-Hydroxyhexyl)-17,28-Dimethyloxacyclooctacosa-17,19,21,23,25-Pentaen-2-One, Filimarisin, Filipin Iii From Streptomyces*Filipinensis, NSC 3364, NSC 38092, Oxacyclooctacosa-17,19,21,23,25-pentaen-2-one, 4,6,8,10,12,14,16,27-octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-, (3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-, Oxacyclooctacosane, filipin III deriv., [3R-[3R*(R*),4S*,6S*,8S*,10R*,12R*,14R*,16S*,17E,19E,21E,23E,25E,27S*,28R*]]-4,6,8,10,12,14,16,27-Octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one, Filipin

Beschreibung

Filipin III is a polycyclic aromatic hydrocarbon isolated from coal tar. It is an immunosuppressant that has been shown to inhibit the production of tumor necrosis factor-α (TNF-α) and interleukin-2 (IL-2). Filipin III also has anti-inflammatory effects, which have been demonstrated in mice with bowel disease by inhibiting the production of inflammatory cytokines such as IL-1β and TNF-α. Filipin III also inhibits toll-like receptor signaling, which may be due to its ability to inhibit NFκB activation. Filipin III binds to DNA and induces a conformational change in the DNA sequence, which prevents transcription and replication.

• Marke: Biosynth

Chemische Eigenschaften

• Reinheit: Min. 95%