Ibrutinib - Bio-X ™

CAS: 936563-96-1

Ref. 3D-BI164531

Produktinformation

• Name: Ibrutinib - Bio-X ™
• Synonyme: 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-onePCI 32765
• Marke: Biosynth
• Beschreibung: Ibrutinib is a small-molecule inhibitor of Bruton’s tyrosine kinase, a crucial enzyme to the B-cell receptor pathway. Bruton’s tyrosine kinase becomes continuously activated in B-cell cancers and therefore promotes the survival of tumor cells. Ibrutinib binds irreversibly and covalently to a cysteine residue within the ATP-binding site of the enzyme, thus preventing ATP binding and downstream signal transduction. The ability of Ibrutinib to inhibit Bruton’s tyrosin kinase and hence the B-cell receptor pathway it can be used in the treatment of some B cell cancers such as diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL).

Chemische Eigenschaften

• Molekulargewicht: 440.5 g/mol
• Formel: C₂₅H₂₄O₂N₆
• Reinheit: Min. 95%
• Farbe/Form: Powder