LSN 3154567

CAS: 1698878-14-6

Ref. 3D-BL165041

Produktinformation

• Name: LSN 3154567
• Synonyme: 2-Hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-1-propanesulfonamide

Beschreibung

Nicotinamide phosphoribosyl transferase (NAMPT) competitive inhibitor with IC50 = 3.1 nM. A major consequence of NAMPT inhibition is the attenuation of glycolysis at the GADPH step because this enzyme requires NAD+ for activity. The compound exhibits broad spectrum anti-cancer activity and significant tumor regression was observed in vitro. Although retinal and haematological toxicity has been associated with NAMPT inhibitors, LSN 3154567 does not lead to retinopathy in rats and can be mitigated with co-administration of nicotinic acid.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 419.5 g/mol
• Formel: C₂₀H₂₅N₃O₅S
• Reinheit: Min. 95%
• Farbe/Form: Powder