Squarunkin A

CAS: 2101958-02-3

Ref. 3D-BS168651

Produktinformation

• Name: Squarunkin A
• Synonyme: 4-[[3,4-Dioxo-2-[[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]amino]-1-cyclobuten-1-yl]amino]-1-piperidinecarboxylic acid, ethyl ester

Beschreibung

Selective inhibitor of the interaction between the UNC119 chaperone and its cargo. Squarunkin A inhibits activation of Src kinase by interrupting the interaction between the myristoylated peptide at the N-terminus of the Src kinase and UNC119A chaperone (IC50 = 10 nM). Squarunkin A impairs the UNC119-mediated enrichment of plasma membrane with non-receptor protein tyrosine kinase Src, resulting in the decrease in Src autophosphorylation and decreased oncogenic Src signalling.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 523.55 g/mol
• Formel: C₂₅H₃₂F₃N₅O₄
• Reinheit: Min. 95%
• Farbe/Form: Solid